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microRNA在肺癌早期诊断及预后中的应用 被引量:4

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摘要 microRNA(miRNA)是基因表达的重要调节因子,其参与人体多种生理过程,以保证人体细胞的各种生命活动的动态平衡。研究表明,miRNA参与肿瘤的病理生理过程。miRNA已成为癌症研究领域的热点。miRNA作为癌组织及患者体液中的特殊肿瘤标记在肿瘤的早期诊断及预后判断中具有重要价值。该文简要回顾miRNA与肺癌相关性研究,并对miRNA作为特殊的肿瘤标志物在肺癌的早期诊断、预后中的应用进行综合分析。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2013年第11期1232-1234,共3页 Chinese Journal of Clinical and Experimental Pathology
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  • 1Bach P B, Silvestri G A, Hanger M, Jett J R. Screening for lung cancer: ACCP evidence-based clinical practice guidelines(2nd e- dition) [J]. Chest, 2007,132(S3) :69 -77.
  • 2Lee R C, Feinbaum R L, Ambros V, et al. elegans heterochronic gene hn-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993,75(6):843-52.
  • 3Calin G A, Dumitru C D, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia[ J ]. Proc Natl, 2002,99 (20) :524 -9.
  • 4Takamizawa J, Konishi H, Yanagisawa K, et al. Reduced expres- sion of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival [ J ]. Cancer Res, 2004,64 (12) :3753 -6.
  • 5Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic mi- croRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation[ J]. Cancer Res, 2005,65 (21) :9628 -32.
  • 6Gao W, Yu Y, Cao H, et al. Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is ,'elated to clinicopathologic characteristics or patient prognosis [ J ]. Biomed Pharmacother, 2010,64 ( 12 ) :399 - 408.
  • 7Markou A, Tsaroucha E G, Kaklamanis L, et al. Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non- small cell lung cancer by quantitative real-time RT-PCR[ J]. Clin Chem, 2008,54(10) :1696 -704.
  • 8Rabinowits G, Gercel-Tay/or C, Day J M, et al. Exosomal mi- croRNA: a diagnostic marker for lung cancer [ J ]. Clin Lung Cancer, 2009,10 ( 10 ) :42 - 6.
  • 9Volinia S, Calin G A, Liu C G, et al. A microRNA expression signature of human solid tumors defines cancer gene targets [ J ]. Proc Natl Acad Sic USA, 2006,103(7) :2257 -61.
  • 10Lebanony D, Benjamin H, Gilad S, et al. Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsqua- mous non-small-cell lung carcinoma[ J ]. J Clin Oncol, 2009,27 (2) :2030 -7.

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