摘要
目的评价小儿咳喘宁口服液治疗呼吸道合胞病毒(RSV)感染毛细支气管炎急性期的临床疗效。方法 68例RSV毛细支气管炎急性期患儿随机分为治疗组与对照组各34例,两组均采用西医常规对症治疗,治疗组加服小儿咳喘宁口服液,疗程7天。对患儿咳嗽、喘憋、喉中痰鸣、肺部啰音症状、体征进行评分,并观察Bierman病情评分的改善情况。于治疗前后进行尿白三烯E4(LTE4)测定。结果治疗组临床疗效总有效率(97.05%)优于对照组(88.24%)(P<0.05)。治疗组在改善咳嗽、喉中痰鸣、肺部啰音等症状、体征及缩短住院天数方面均优于对照组(P<0.01)。治疗后3天治疗组喘憋评分及Bierman评分明显低于对照组(P<0.05)。两组患儿尿LTE4治疗前后比较差异均有统计学意义(P<0.05),但两组治疗后7天组间比较差异无统计学意义(P>0.05)。结论小儿咳喘宁口服液可改善RSV感染毛细支气管炎急性期患儿咳嗽、喘憋、喉中痰鸣及肺部啰音等症状体征,缩短住院天数,提高临床疗效。
Objective To study the therapeutic effect and mechanism of Xiaoer Kechuanning Oral Liquid(oral liquid for pediatric cough and asthma)for respiratory syncytial virus(RSV)infection and bronchiolitis.Methods Totally 68children with RSV infection and bronchiolitis were randomized into the treatment group and control group.Both groups were given routine western medicine.The treatment group was added with Xiaoer Kechuanning Oral Liquid.The treatment lasted for 7 days.The improvement of coughing,wheezing,throat phlegm,pulmonary rales and Bierman's score was observed.The level of urinary leukotriene E4(LTE4)was detected before and after treatment.Results The total effective rate of the treatment group and control group was 97.05%and 88.24%respectively,with a significant difference between groups(P<0.05).The treatment group was superior to the control group in relieving coughing,throat phlegm and pulmonary rales and shortening hospital stay(P<0.01).On the 3rd day after treatment,the wheezing score and Bierman's score in the treatment group were significantly lower than that in the control group(P<0.05).The levels of LTE4were significantly decreased in both groups after treatment(P<0.05),but with no significant difference between groups on the 7th day after treatment(P>0.05).Conclusion Xiaoer Kechuanning Oral Liquid is effective for RSV infection and bronchiolitis in children and it can relieve coughing,wheezing,throat phlegm and pulmonary rales,shorten hospital stay and increase clinical efficacy.
出处
《中医杂志》
CSCD
北大核心
2013年第20期1747-1750,共4页
Journal of Traditional Chinese Medicine
基金
广东省中医药局2011年建设中医药强省科研课题(20112118/2011KT177)
