摘要
目的探讨羊水表皮生长因子浓度与胎儿肺泡成熟度的关系。 方法对 16 8例胎龄在 2 1～ 42周的孕妇 ,采用羊膜腔穿刺术采集羊水。分别以薄层层析法和放射免疫法测定卵磷脂 /鞘磷脂比值 (L/S)和表皮生长因子(EGF)。 结果羊水L/S比值及EGF浓度均与胎龄呈正相关 (r值分别为 0 .86和 0 .87,P值均 <0 .0 1)。羊水EGF浓度与L/S比值有显著的相关性 (r =0 .76 ,P <0 .0 0 1)。 结论羊水表皮生长因子与胎儿肺泡成熟度密切相关。
Objective To evaluate the relationship between amniotic fluid(AF) epidermal growth factor(EGF) concentration and fetal pulmonary maturation. Methods Lecithin-sphingomyelin ratio (L/S) and EGF were measured in amniotic fluid from women(n=168,21 ～ 42 weeks' gestation) undergoing amniocentesis by TLC and RIA. Results The AF L/S ratio and EGF concentration increased linearly with Gestational age(GA) (r=0.86 and 0.87, respectively, P<0.01). There was a strong correlation between the AF L/S ratio and EGF(r=0.76, P<0.001). Conclusion There are a confirmed relationship between AF EGF levels and fetal pulmonary maturation.
出处
《上海第二医科大学学报》
CSCD
2000年第6期529-530,共2页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
表皮生长因子
胎儿
肺泡成熟度
epidermal growth factor-urogastrone
fetal
pulmonary maturation
