摘要
目的 为了探讨血清胃泌素的变化与食管癌之间的相互关系。方法 对 4 5例食管癌病人及 30例正常人 ,采用放射免疫测定技术对其进行了空腹血清胃泌素浓度的检测。结果 食管癌病人空腹血清胃泌素值为 ( 168 3± 4 6 2 )Pg ml ,非常显著的高于正常对照组的 ( 4 8 3± 2 4 9)Pg ml(P <0 0 0 1) ;伴有淋巴结转移者为 ( 12 1 7± 4 7 6)Pg ml ,非常显著高于无淋巴结转移的 ( 51 7±32 3)Pg ml(P <0 0 1) ;癌肿浸润深度达肌层以外者为 ( 168 3± 4 0 3)Pg ml,显著高于癌肿浸润达肌层以内者的 ( 78 9± 34 7)Pg ml(P <0 0 1)。结论 空腹血清胃泌素浓度的测定 ,对食管癌病期的判断 ,治疗及预后的评估均有一定的意义。
Objective To Study pathologic physiology in the patients of Esophageal cancer with the levels of serum gastrin.Methods A radioimmunological assay was used to determine the levels of serum gastrin in 45 patients with the Esophageal cancer and 30 health controlpersons.Results The mean levels of serum gastrin in the patients of Esophageal cancer was 168.3±46.2Pg/ml,and was singnificantly higher than that in control group 48.3±24.9Pg/ml( P <0.001).The mean level of serum gastrin was 121.7±47.6Pg/ml in the patients with lymph node metastasis,in contrast to 51.7±32.3Pg/ml( P <0.01) in the patients without lymph node metastasis.The level of serum gastrin was 134.6±40.3Pg/ml in the patients in whom the cancer cells have penetrated the mucosal musculature to the muscularis externa,and this valus was significantly higher than that 78.9±34.7Pg/ml( P <0.01) in the Patients in whom the cancer cells only invaded the mucosal musculature.Conclusion It is suggested that measurement of serum gastrin may be a guide for diagnosis and prognosis evaluation of Esophageal cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2000年第6期462-463,共2页
Cancer Research on Prevention and Treatment
关键词
食管癌
血清胃泌素
放射免疫测定
Esophageal cancer
Serum gastrin
Radioimmunoassayt
