摘要
本文采用放射免疫测定技术对３５例贲门癌病人及３０例正常人空腹进行了血清胃泌素浓度的检测，结果贲门癌病人空腹血清胃泌素水平（１９１．４±４６．３Ｐｇ／ｍｌ）显著高于正常对照组（４８．３±２４．９Ｐｇ／ｍｌ）；有淋巴结转移者（１０７．３±４０．６Ｐｇ／ｍｌ）显著高于无淋巴结转移者（４９．３±３１．６Ｐｇ／ｍｌ）；癌肿浸润粘膜肌层以外者（１１３．７±４１．３Ｐｇ／ｍｌ）显著高于癌肿浸润粘膜肌层以内者（６２．８±３７．１Ｐｇ／ｍｌ）；分化良好的腺癌病人（９２．４±４３．８Ｐｇ／ｍｌ）较低分化腺癌病人（１０９．４±５１．３Ｐｇ／ｍｌ）无显著差异性。研究结果表明：空腹血清胃泌素测定有助于探讨胃泌素与贲门癌的关系、诊断以及预后的判断。
A radioimmunological assay was used to determine the levels of serum gastrin in 35 patients with adenocarcinoma of the gastric cardia and in 30 health control persons. The mead level of serum gastrin in the patients with carcinoma of the gastric caedia was 191. 4±46. 3pg/ml, and was significantly higher than that in control group (48. 3±24. 9pg/ml). Noreover, the mean level of serum gastrin was 107. 3±40. 6pg/ml in the patients with lymph node metastasis, in contrast to 49. 3±31. 6pg/ml in the patients without lymph node metastasis. The level of serum gastrin was 113. 7±41. 3pg/ml in the patients in whom the cancer cells have penetrated the mucosal musculature to the muscularis externa, and this value was significantly higher than that (62. 8±37. 1pg/ml) in the patients in whom the cancer cells only invaded the mucosal museulature. The mean levels were 92. 4±43. 8pg/ml in the patients with well differentiaved adenocarcinima and 109. 4± 51. 3pg/ml in the patients with Poorly differentiated adenocarcinoma,however,the difference was not statistically significant. It is suggested that measurement of serum gastrin may be a guide for diagnosis and prognostic evaluation of carcinoma of the gastric cardia.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1995年第4期227-229,共3页
Cancer Research on Prevention and Treatment
