摘要
为研究铬 (Cr)对大鼠体重的影响及其与瘦素和胰岛素的关系 ,将 80只大鼠按体重随机分为 8组 ,分别为基础饲料对照组、3个基础饲料实验组 [葡萄糖酸铬 ,相当于每天摄入 Cr( ) 1、2和 3mg/ kg BW]、高脂饲料对照组、3个高脂饲料实验组 (铬含量同上 )。每周称重 1次 ,并于第 8周末断头取血 ,用放射免疫法分别检测血清中的瘦素及胰岛素 ,同时称取大鼠的肝、脾、肾和睾丸 ,计算脏 /体比值。结果显示 ,高脂饲料组与基础饲料组相比 ,大鼠体重显著增加 (P<0 .0 5 ) ,胰岛素和瘦素水平显著升高 (P<0 .0 5 ) ;而无论是基础饲料组还是高脂饲料组 ,随着铬剂量的增加 ,胰岛素和瘦素水平均显著降低 (P<0 .0 5 )。揭示铬对大鼠体重影响不大 。
In order to observe the effect of chromium on rat body weight, serum leptin and insulin, eight groups of rats were randomly fed diets(basal diet or high fat diet)with different levels of chromium gluconate [proximally Cr(Ⅲ) 1,2 and 3mg/kg BW]. All rats were weighted once a week. By the end of the 8th week, all rats were decapitalized and the levels of serum leptin and insulin were tested by RIA method. The ratio of liver, spleen, kidney and testickle to body weight were calculated. The average body weight and the levels of leptin and insulin of high fat diet groups were significantly higher than those of the basal diet group ( P <0 05), but the insulin and leptin of groups with chromium were signficantly lower than their corresponding control groups without chromium( P <0 05). It was concluded that chromium could cause weight loss slightly and reduce the levels of insulin and leptin.
出处
《卫生研究》
CAS
CSCD
北大核心
2000年第6期370-371,共2页
Journal of Hygiene Research
基金
国家自然科学基金!(No.396 70 6 38)
