摘要
气体植物激素乙烯在植物生长发育及应对胁迫的防御反应中起重要调控作用.通过20多年的研究,利用模式植物拟南芥,勾画出一条自内质网膜受体至细胞核内转录因子的线性乙烯信号转导通路.本文概述了研究乙烯信号转导的方法及乙烯信号转导的基本过程;阐述了最新发现的乙烯信号从内质网膜传递到细胞核的分子机制,即原本定位于内质网膜上的EIN2蛋白其C端被剪切之后进入细胞核,然后通过抑制EBF1/2而稳定转录因子EIN3/EIL1;根据最近多个小组报道EIN3/EIL1直接调控除乙烯响应基因之外的其他生物学过程相关基因,提出了EIN3/EIL1可以作为网络节点整合多条信号通路的新观点;通过分析不同信号通路调控EIN3/EIL1的方式,发现不仅EIN3/EIL1的蛋白稳定性受到调控,而且其转录活性还受到诸如JAZ,DELLA等转录调节因子的调控.本文展望了未来乙烯信号转导通路的研究方向与研究热点.
The simple gaseous phytohormone ethylene influences an extensive array of developmental processes and stress-resistance responses in plants. Based on molecular genetics studies, a nearly linear ethylene signaling pathway from endoplasmic reticulum （ER） membrane-bound receptors to nuclear-localized transcription factors has been established in the model plant Arabidopsis during the past two decades. In this review, we firstly summarize the approaches used to study ethylene signal transduction and depict the overall picture of ethylene signaling pathway. Then, we focus on the latest discovery of the cleaved EIN2 carboxyl terminus （CEND） translocating from ER membrane to the nucleus and promoting the accumulation of EIN3/EIL1 by repressing the activity of EBF1/2. We also propose that EIN3/EIL1 act as a hub in plant signaling networks that senses a broad range of stimuli and integrates these stimuli to shape plant growth, development and stress resistance. A collection of regulators, such as JAZ and DELLA proteins, have been identified recently mechanisms including protein stability and transcriptional ethylene action are raised and briefly discussed. to modulate the functions of EIN3 and EIL1 by different activity. In the end, several interesting questions regarding
出处
《中国科学：生命科学》
CSCD
北大核心
2013年第10期854-863,共10页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:91017010)
转基因生物新品种培育科技重大专项(批准号:2010ZX08010-002)资助项目
