摘要
多肽和蛋白质药物具有作用靶点专一、不良反应少和生物活性强等特点,已成为临床治疗疾病的重要药物,但受到酸屏障、酶屏障和膜屏障的影响,限制了这类药物的口服吸收。多肽和蛋白质药物口服给药方便、可提高患者依从性,其口服制剂的研发是近20年来生物制药领域的热点。近年来,通过多肽和蛋白质药物化学修饰、吸收促进剂、酶抑制剂、纳米粒载体、脂质体载体、微乳载体、定位释放和基因工程等方法提高其口服吸收的可能性。本文对多肽和蛋白质药物口服的吸收机制、影响因素、提高口服吸收的策略等方面进行了综述。
Peptide and protein drugs （PPD） play an important role in clinical applications because of specific targets, limited adverse reactions and strong biological activity. Some barrier systems including acids, enzymes and biomembranes prevent PPD from absorption by oral administration. Oral delivery of peptides and proteins is desirable to patients and will improve their compliance. PPD has been one of the most intensively studied research subjects in the field of biological pharmacy over the past twenty years. This paper reviewed mechanisms of oral absorption of peptides and proteins, factors that hamper absorption of PPD and strategies to improve absorption of PPD in the gastrointestinal tract.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2013年第5期903-907,共5页
Chinese Journal of Pharmacology and Toxicology
基金
浙江省自然科学基金(Y3110051)
浙江省科技厅公益性技术应用研究项目(2012C22053)
国家科技重大专项(2012ZX09102301-009)
浙江理工大学科研启动基金(1016846-Y)~~
关键词
生物药学
多肽
蛋白质
投药
口服
吸收
biopharmaceutics
polypeptides
protein
administration, oral
absorption
