摘要
壳聚糖是目前发现的唯一与细胞外基质糖胺聚糖的化学结构相似的天然阳离子多聚糖,具有极为优良的生物相容性、生物可降解性和生物学活性。近年来,基于壳聚糖的纳米材料在组织工程中的研究较为广泛。对壳聚糖的纳米材料、壳聚糖复合纳米材料、壳聚糖纳米纤维和壳聚糖纳米粒子等在骨组织工程与再生医学中的研究进展进行回顾和阐述。近年来的研究显示,壳聚糖复合纳米材料生物支架、壳聚糖纳米纤维支架及包载具有骨诱导性的生物活性因子,以及外源基因的壳聚糖纳米粒子及纳米纤维,在骨组织工程与再生医学中具有良好的应用前景。
Chitosan is the only one natural cationic polysaccharide possessing similar chemical structures to extracellular glycosaminoglycan. Chitosan has excellent biocompatibility, biodegradability as well as biological activity. In the past decade, chitosan-based nanomaterials have been widely studied in bone tissue engineering. The present paper reviews the researches and application potentials of chitosan nanocomposites, chitosan nanofibers and chitosan nanoparticles in biomedical fields. Investigation results show that chitosan nanocomposites, chitosan nanofibrous scaffolds and chitosan nanoparticles loading biological active factors and exogenous genes have wide promising potentials for bone tissue engineering and regenerative medicine.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2013年第5期620-625,共6页
Chinese Journal of Biomedical Engineering
基金
浙江省自然科学基金项目(Y2110260)
杭州市科技局科技发展计划项目(20090833B02)
卫生部省部共建项目(WKJ2009-2033)
关键词
壳聚糖
纳米材料
骨组织工程
chitosan
nanomaterials
bone tissue engineering
