摘要
复发性自然流产病因繁杂,目前已知的病因主要包括遗传因素(染色体数量和结构异常、单基因活性改变或突变等)、解剖因素(先天性子宫发育异常、子宫获得性异常、子宫血管异常等)、免疫因素(自身免疫抗体形成、封闭抗体减少、辅助性T淋巴细胞因子失衡、NK细胞活性增强等)、内分泌因素、感染因素、母亲躯体及心理健康和环境因素等。然而,仍有50%的复发性自然流产病因不明。
The etiology of recurrent spontaneous abortion （RSA） is very complex. The known causes of RSA include genetics factors （the abnormalities of chromosome number and structure, copy number variation and the mutation of single-gene）, anatomic factors （congenital and acquired morphological abnormali- ties of uterine, uterine vascular malformation）, immunologic factors （auto-antibodies formation, the lack of blocking antibodies, the imbalance of T-helper lymphocyte cytokine, increased activity of natural killer cell）, endocrinological dysfunction, infection, maternal physical and psychological health problems, environmental factors. However, the causes of about 50% RSA cases remain to be clarified.
出处
《生殖与避孕》
CAS
CSCD
2013年第10期701-706,共6页
Reproduction and Contraception
