摘要
肝癌的发生发展与癌基因的过表达或者抑癌基因的低表达密切相关。Sirtuin家族是一类依赖NAD＋的组蛋白去乙酰化酶。它们通过与多种组蛋白及非组蛋白相互作用，在代谢调节、抗衰老、炎症反应以及肿瘤发生发展等过程发挥着重要作用。近来越来越多的证据显示SIRT1能够使抑癌基因去乙酰化从而促进肝癌的发生。然而，另一方面，SIRT1也能够降低代谢相关的肝癌小鼠成瘤率。本文就sirtuin家族成员在肝细胞癌发生发展中的表达及临床意义作一综述。
Hepatocellular carcinoma （HCC） development is closely related to overexpression of tumor promoters or down-regulation of tumor suppressors. The mammalian sirtuin family was found to be a nicotinamide adenosine dinucleotide （ NAD/NADH ）-dependent histone deacetylase （HDAC） ,which implicated in the regulation of critical biological processes through deacetylation modifying on histone and nonhistone. SIRT1 can regulate metabolism, aging, in- flammation and cancer progression. In particular, more and more evidence proves that SIRT1 can act as a tumor promoter in hepatocellular carcinoma through deacetylation on tumor suppressors. On the other hand, SIRT1 can strongly suppress metabolic syndrome-associated liver cancer in the mouse model. This review will discuss the expression of sirtuin family member in liver cancer and its clinical significance.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2013年第10期789-793,共5页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金重点项目（81030041）
