摘要
过去几十年里,达尔文创立的生物进化论及孟德尔确立的遗传学说为家禽选育及品种的改良奠定了理论基础,并显著改善了禽肉品质,提高了家禽生产力。尽管遗传选择能够主导亲代基因传递给后代,但越来越多的证据表明营养等环境因素对基因表达具有重要的修饰作用。表观遗传学是研究在核苷酸序列不变的情况下,基因表达的可遗传变化的一门遗传学分支学科。本文主要讨论了家禽营养对DNA甲基化的影响,以及这种影响通过生殖细胞的表观遗传重塑可以成功地传递给后代的现象。
Over the past few decades, the theories of biological evolution founded by Darwin and genetics established by Mendelian laid the theoretical foundation for the poultry breeding and the improvement of breed- ing, which significantly improve the quality of poultry meat and enhance the poultry productivity. Genetic se- lection not only is able to dominate the parental gene, but also can transmit through successive generations. Mounting evidence suggests that environmental factors, such as nutritions play an important role in the modifi- cation of gene expression. However, epigenetics refers to the changes in gene expression that occurs without any change in DNA sequence, which has become an important subdiscipline within genetics. The article focused on the influence of poultry nutrition on DNA methylation, and the phenomenon that this influence can be successfully inherited by the offspring through the genetic remodeling of germ cells.
出处
《动物营养学报》
CAS
CSCD
北大核心
2013年第10期2192-2201,共10页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
营养学国家重点实验室自主研究课题(2004DA125184G1101)
国家肉鸡产业技术体系经费资助(CARS-42)
