摘要
目的:观察宁痛片对偏头痛模型大鼠行为学和硬脑膜肥大细胞数目的影响。方法:将50只Wistar大鼠随机分为5组:正常组、模型组、对照组、治疗大剂量组及治疗小剂量组,分别灌胃7 d,尾静脉注射硝酸甘油造偏头痛大鼠模型,观察造模后2 h大鼠行为学症状,造模后4 h取硬脑膜,观察单位面积肥大细胞数目。结果:与模型组比较,宁痛片改善大鼠行为症状,减少硬脑膜肥大细胞数目。结论:宁痛片能改善模型大鼠偏头痛症状,起到阵痛作用。
Objective ： To observe the effect of Ningtong tablet on behavior and dura mast cells in migraine rats. Methods ： Fifty Wistar rats were randomly divided into 5 groups, each of 10 rats： normal group, model group, control group, treatment of high dose group and treatment of low dose group. After intragastric administration of 7 days, nitroglycerin was injected through caudal vein to induce migraine model. To observe the behavior of model rats after 2 hours and the number of dural mast cells after 4 hours. Result ： Compared with the model group, the behavior of treatment groups were improved significantly, and the number of mast ceils were decreased. Conclusion ： Ningtong tablet can improve the symptoms of migraine model rats, and relieve pain.
出处
《辽宁中医药大学学报》
CAS
2013年第11期17-18,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
天津市中医药管理局科研课题(11004)
