摘要
研究发现幼年和老年大鼠在条件性饮水反应的建立、消退和再建立过程中,海马CA_3区有习得性长时程突触增强(LTP)的形成、消退和再形成现象。在它的形成和再形成以及每实验日训练作业后习得性LTP的发展上,幼年鼠明显快于老年鼠,而习得性LTP的消退,在两组间无明显差异。这既表明海马CA_3区的习得性LTP具年龄特征,也为论证习得性LTP可能是学习和记忆的神经基础之一提供了新的证据。
The learning-dependent long-term potentiation (LTP) in the hippocampal CA3 region of the young and aged rats all was changed obviously during the establishment, extinction and re-establishment of conditioned drink response. The velocity of establishment and development of the learning-dependent LTP in CA3 of the young rats is more than that of the aged rats. However there was nonsignificant difference in the extinction of the learning-dependent LTP in CA3 of the young and the aged rats. These results not only showed that there was the age characteristics of the learning-dependent LTP in the CA3 region but also provided a evidence that the learning-dependent LTP might be one of the neural bases of learning and memory.
基金
国家自然科学基金资助项目
关键词
大鼠
学习
海马CA3区
长时程突触
Hippocampal CA_3 region, Long-term potcntiation of the synaptic efficacy, Learning, Memory, Age characteristics
