摘要
目的:观察参附注射液对脓毒症患者心肌损伤的保护作用。方法:将55例脓毒症及脓毒性休克伴发心肌损伤患者随机分为对照组(25例)和治疗组(30例)。所有患者均给予抗感染、保护器官功能、营养支持及对症治疗,对照组在此基础上采用极化液(10%葡萄糖注射液500 ml+胰岛素8 U+10%氯化钾注射液10 ml)静脉滴注,qd;治疗组在对照组基础上采用参附注射液100ml加入5%葡萄糖注射液250 ml中静脉滴注,qd。两组均连用2周。观察两组患者治疗1、5、10 d后血肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、丙二醛(MDA)和超氧化物歧化酶(SOD)等指标变化,并观察不良反应情况。结果:治疗组患者治疗5、10 d后CK、CK-MB、cTnT、MDA水平均较治疗1 d后显著降低,且显著低于对照组(P<0.05);SOD水平均较治疗1 d后显著升高,且显著高于对照组(P<0.05)。两组均未见不良反应发生。结论:参附注射液具有抗氧自由基和抗脂质过氧化作用,能在一定程度上减轻脓毒症患者的心肌损伤,且安全性较好。
OBJECTIVE： To observe the protective effects of Shenfu injection against myocardial injury in septic patients. METHODS： 55 patients with sepsis or sepsis shock complicating with myocardial injury were randomly divided into control group （25 cases） and treatment group （30 cases）. Both groups were given anti-infective therapy, organs protection, nutritional support and symptomatic treatment. Control group was additionally treated with polarized solution （10% Glucose injection 500 ml ＋ insulin 8 U＋10% Potassium chloride injection 10 ml）, i.v., once a day; treatment group was additionally given intravenous dripping of Shenfu injection 100 ml in 5% Glucose solution 250 ml once a day on the basis of the treatment of control group. The course of treatment in two groups was 2 weeks. The levels of CK, CK-MB, cTnT, MDA and SOD of 2 groups were observed 1, 5 and 10 days after treatment. Adverse drug reaction was also observed. RESULTS ： Compared with a day after treatment, the levels of CK, CK-MB, cTnT and MDA in treatment group were decreased significantly 5 and 10 days after treatment, which were significantly lower than in control group （P〈0.05） ; the level of SOD was increased significantly, and higher than in control group （P〈0.05）. No adverse drug reaction was found in both groups. CONCLUSIONS： Shenfu injection has anti-oxide free radical effect and an- ti-lipid peroxidation effect, and relieves myocardial injury of sepsis patients with sound safety to some extent.
出处
《中国药房》
CAS
CSCD
2013年第40期3790-3792,共3页
China Pharmacy
