摘要
目的 探讨经常性的有氧运动对特发性中枢性性早熟 (ICPP)女孩生长和促生长素轴功能的影响。方法 9例ICPP女孩单纯运动治疗 (5 1± 1 6 )个月 ,比较其运动治疗前后生长、发育以及GH -IGF - 1轴的功能。结果 ICPP女孩单纯运动治疗后在性腺不抑制的情况下生长速度显著加快 ,身高年龄与骨龄的比值显著增加 ,空腹血清骨钙素、胰岛素样生长因子 1(IGF - 1)水平显著增加 ,胰岛素样生长因子结合蛋白 3(IGFBP - 3)水平及IGFBP - 3/IGF - 1比值显著降低。结论 经常性的有氧运动能作为促进ICPP女孩实现生长和成熟正平衡、改善成年身高的有效辅助干预手段。
Objective\ To study the effects of regular aerobic exercise on growth and GH-IGF-1 axis function in girls with idiopathic central precocious puberty(ICPP).Method\ 9 girls with ICPP accepted isolated exercise treatment for (5 1±1 6)months.The auxological and biological parameters of growth and development before treatment were compared with those after treatment.Results\ After exercise treatment,both growth rate and the ratio of height and bone age increased significantly on condition of no sexual inhibition,both serum osteocalcin and IGF-1 level increased while serum IGFBP-3 level and IGFBP-3/IGF-1 decreased significantly.Conclusion\ Regular aerobic exercise may be regarded as an effective assistant interventional means for facilitating the positive equilibrium between growth and sexual maturation and improving their final height in girls with ICPP.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第11期666-668,共3页
Chinese Journal of Practical Pediatrics
