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TrkA、p75NTR在神经系统中的研究进展 被引量：4

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摘要 神经生长因子(nerve growth factor,NGF)在神经损伤修复、促进细胞生长、分化等过程中具有极重要作用。其受体分为两大类,一类是高亲和力受体TrkA,另一类是低亲和力受体p75神经营养素受体(p75 neurotrophin receptor,p75NTR),p75NTR在不同的配体、协同受体、拮抗受体以及含量、活性比例参与引起不同生物学效应,除可促进神经细胞生长、维持存活,还可诱导凋亡、抑制轴突生长等。NGF结合TrkA后对神经元产生效应包括神经元的存活、分化、轴突生长、突触可塑性等。P75NTR、TrkA二者间的信号转导与生物学效应相互协同但又彼此拮抗。
作者 钟湘平 廖勇仕
机构地区 南华大学附属第二医院神经外科
出处 《社区医学杂志》 2013年第19期14-17,共4页 Journal Of Community Medicine
关键词 神经生长因子 TRKA p75神经营养素受体 神经细胞 神经系统
分类号 R338 [医药卫生—人体生理学]
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参考文献28

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共引文献19

同被引文献35

  • 1魏传银,王丽梅,陈雪红,路长林,耿美玉.神经营养素受体p75^(NTR)介导的信号转导[J].细胞与分子免疫学杂志,2005,21(2):258-260. 被引量：8
  • 2于立明,张伟,吴亚东,王子莹.神经生长因子受体(TrkA)在下颌骨骨折愈合中的表达及意义的研究[J].中国实验诊断学,2006,10(7):768-770. 被引量：12
  • 3刘宇,邓宇斌,周丽华.p75NTR介导神经细胞凋亡研究进展[J].生命科学,2007,19(1):63-67. 被引量：4
  • 4张风河,魏奉才,杨丕山,孙善珍.p75NTR对小鼠面神经损伤后脑内神经元再生的影响[J].口腔颌面外科杂志,2007,17(2):139-142. 被引量：2
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引证文献4

二级引证文献16

社区医学杂志
2013年 第19期

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