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眼底病变与Toll样受体的研究进展 被引量：2

Current study of Toll-like receptor and fundus disease
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摘要 Toll样受体（TLRs）可以识别外源性病原微生物的病原相关分子模式，激活下游信号通路，参与固有免疫和适应性免疫应答，也可以识别各种内源性的危险信号分子，参与各种慢性轻度炎症性疾病和自身免疫性疾病的发病过程。TLRs主要在各种免疫细胞上表达，近来研究证实视网膜色素上皮（RPE）细胞上也有TLRs的表达。TLRs参与外源性病原微生物和内源性危险信号分子引起的眼部炎症反应、参与RPE细胞对感光细胞外节段的吞噬及眼底新生血管形成。本文从以上几方面探讨TLRs与眼底病变关系的研究进展。 Toll-like receptors （TLRs） can recognize pathogens associated molecular of micro-organisms, leading to activation of the downstream signal transduction pathway and participate in innate and adaptive immune response. TLRs can also recognize endogenous danger signaling molecule and therefore be involved in pathogenesis of many low-grade chronic inflammatory and autoimmune diseases. TLRs are always expressed on immune cells, and recent studies confirmed that retinal pigment epithelial （RPE） ceils also express TLRs. This review focuses on the research progress of fundus diseases and TLRs, such as the recognition of exogenous pathogenic microorganisms and endogenous danger signals in fundus,induction of inflammatory response,phagocytosis of photoreceptor outer segment by RPE and angiogenesis of fundus diseases.
作者 陈雪梅(综述) 张学东(审校)
机构地区 重庆医科大学第一附属医院眼科重庆眼科学重点实验室
出处 《中华实验眼科杂志》 CAS CSCD 北大核心 2013年第10期988-991,共4页 Chinese Journal Of Experimental Ophthalmology
关键词 TOLL样受体 眼底病变 新生血管 炎症 Toll-like receptors Fundus disease Angiogenesis Inflammation
分类号 R392.11 [医药卫生—免疫学]
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参考文献23

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二级参考文献13

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共引文献9

同被引文献29

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二级引证文献6

中华实验眼科杂志
2013年 第10期

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