摘要
以对硝基苯甲酸乙酯为原料,Pd/C为催化剂,甲酸铵为供氢体,乙醇为溶剂,对在室温下反应得到对氨基苯甲酸乙酯的催化转移氢化反应进行了研究.在相同的催化体系下,本佐卡因的类似物也得以高效合成.该催化转移氢化反应除温和的反应条件和高催化活性外,还兼具良好的放大前景.
The catalytic transfer hydrogenation of ethyl p-nitrobenzoate to ethyl 4-aminobenzoate is studied at room temperature with ammonium format as the hydrogen donor and ethanol as the solvent using Pd/C as catalyst.Under the same catalytic condition,the analogs of benzocaine is also synthesized in high yields.The present catalytic transfer hydrogenation reaction can be made under mild reactions conditions with high catalytic reactivity and also shows a great scale-up prospect.
出处
《宁波大学学报（理工版）》
CAS
2013年第4期61-64,共4页
Journal of Ningbo University：Natural Science and Engineering Edition
基金
国家自然科学基金(21202090)
浙江省自然科学基金(LY12B02001)
宁波市科技创新团队项目(2011B82002)
宁波市自然科学基金(2011A610123
2012A610123)
关键词
苯佐卡因
PD
C催化
催化转移氢化
还原
benzocaine
Pd/C catalysis
catalytic transfer hydrogenation
reduction
