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基质金属蛋白酶在类风湿关节炎免疫致病机制及信号转导中的研究进展 被引量：6

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摘要 基质金属蛋白酶（matrix metalloproteinase,MMPs）是一组在结构上具有极大同源性、能降解细胞外基质蛋白的内肽酶的总称,因为含有金属离子锌、钙而得名[1].包括膜型的MMP在内,该家族迄今已发现20余个成员,根据其发现顺序可分为MMP-1～MMP-19,按其作用底物和结构不同又可分为5类：胶原酶类（MMP-1、MMP-8、MMP-13）,明胶酶类 （MMP-2、MMP-9）,基质分解素类 （MMP-3、MMP-7、MMP-10, MMP-11）,膜型金属蛋白酶类 （MT-MMP-14、MT-MMP-15、MT-MMP-16、MT-MMP-17）及其他（MMP-12、MMP-18、MMP-19等）.本文就MMPs的结构、生物学功能、表达调控以及在类风湿关节炎（RA）发病机制中的作用作一综述.
作者 唐艳丽 邵予 孙万邦
机构地区 合肥医学院珠海校区 广东省深圳市龙岗区妇幼保健院儿科 广东省深圳市龙岗区妇幼保健院
出处 《广东医学》 CAS CSCD 北大核心 2013年第17期2724-2727,共4页 Guangdong Medical Journal
基金 贵州省教育厅自然科学重点培育项目(编号:2008032)
关键词 基质金属蛋白酶 类风湿关节炎 免疫致病机制 信号转导 MMP-10 细胞外基质蛋白 金属蛋白酶类 MMP-8
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献36

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共引文献33

同被引文献71

  • 1缪怡,胡朝英,钱柳,张冬青.类风湿性关节炎免疫学研究进展[J].上海交通大学学报（医学版）,2011,31(7):1035-1040. 被引量：40
  • 2魏平,付爽,王俊祥.基质金属蛋白酶3在类风湿关节炎中的表达及其意义[J].临床荟萃,2006,21(19):1389-1390. 被引量：12
  • 3刘奕,郭常安,陈峥嵘.骨关节炎、类风湿关节炎的关节滑液和血清中基质金属蛋白酶-1、2、3和9的含量及意义[J].上海医学,2007,30(1):50-52. 被引量：4
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引证文献6

二级引证文献37

广东医学
2013年 第17期

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