摘要
以间苯二酚、乙酰乙酸乙酯和1,3-丙酮二羧酸为原料,经Pechmann反应和Knoevenagel反应合成了4个7-羟基香豆素类化合物——7-羟基-4-甲基香豆素(1),7-羟基-4-乙酸甲酯香豆素-(2),7-羟基-3-甲酸乙酯香豆素(5)和7-羟基-3-乙酰基香豆素(6)。以四丁基溴化铵为相转移催化剂,1,2,5和6分别经O-异戊烯基化或O-法尼烯基化反应合成了6个7-羟基香豆素类的烯基醚衍生物,其中5个为新化合物,其结构经1H NMR,IR和MS表征。
Four 7-hydroxyl coumarin compounds [7-hydroxyl-4-methyl coumarin （1）,7-hydroxyl-4-methyl acetate coumarin （2）,7-hydroxyl-3-ethyl formate coumarin （5） and 7-hydroxyl-3-acetyl coumarin （6）] were synthesized by Pechmann and Knoevenagel reaction from resorcinol,ethyl acetoacetate and 1,3-acetonedicarboxylic acid.Using tetra-n-butyl-ammonium bromide as the phase transfer catalysis,six vinyl ether derivatives （five of them are new compounds） were synthesized by O-prenylation or O-farnesylation of 1,2,5 and 6 with vinyl bromine,respectively.The structures were characterized by 1H NMR,IR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2013年第5期582-585,共4页
Chinese Journal of Synthetic Chemistry
基金
湖南省教育厅科学研究项目(10B012)
