摘要
由6-氯烟酸出发经两步合成了16个苯氧基-3-乙酰吡啶类中间体,其中14个为新化合物。通过改变缚酸剂缩短了反应时间,提高了收率,与现有文献报道的合成方法相比,具有步骤少、反应时间短、收率高的优点。产物结构经核磁、质谱表征得到确认。
16 Different phenoxy-3-acetylpyridine intermediates was synthesized by two steps starting from 6-ehloronicotinic acid, 14 of which are new compounds. This method can short- en the reaction time and improve the yield by changing the acid-binding agent. Compared with literature methods, this method has the advantages of shorter steps and reaction time, and high yield. The structure of the products were confirmed by 1HNMR,MS.
出处
《化学试剂》
CAS
CSCD
北大核心
2013年第10期871-873,共3页
Chemical Reagents
基金
国家"十二五"科技支撑计划资助项目(2012-BAK25B03)
关键词
二芳醚
吡啶衍生物
合成
diaryl ether
pyridine derivatives
synthesis
