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化疗对绝经前乳腺癌患者月经的影响 被引量：5

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摘要 目的:研究绝经前乳腺癌患者术后辅助化疗对月经的影响。方法:回顾性研究144例绝经前乳腺癌患者化疗后出现闭经的比例、时间以及月经恢复的比例和时间。其中78例接受FEC方案,66例接受TE方案。分析患者的临床特征与化疗致闭经(CIA)及月经恢复的相关性。结果:126例(87.5%)患者出现CIA,其中107例(84.9%)停经出现在前3个疗程后;≤40岁患者CIA的发生率显著低于>40岁的患者(P<0.05),化疗方案及激素受体状态对发生率无统计学差异(P>0.05)。126例出现CIA的患者中共有74例(58.7%)恢复月经,中位时间为化疗结束后5个月;年龄及激素受体状态对CIA的恢复有统计学差异(P<0.05)。结论:年龄是预测CIA出现和月经恢复的指标。激素受体阳性患者服用三苯氧胺对月经恢复有显著影响。
作者 钱超 周文斌 赵志泓 黄中晶 王水
机构地区 江苏大学附属医院甲乳外科 南京医科大学第一附属医院乳腺外科
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2013年第9期1280-1282,共3页 Journal of Nanjing Medical University(Natural Sciences)
关键词 乳腺肿瘤 化学疗法 内分泌治疗 闭经
分类号 R737.9 [医药卫生—肿瘤]
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参考文献15

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二级参考文献22

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共引文献370

同被引文献66

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引证文献5

二级引证文献12

南京医科大学学报（自然科学版）
2013年 第9期

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