摘要
胆管反应是指在肝祖细胞介导的肝脏修复过程中形成的局部细胞复合体。这种复合体包括有激活的肝祖细胞、中间型肝胆细胞和反应胆管细胞。胆管反应对肝癌发生发展具有重要作用。胆管反应中的肝干j祖细胞的恶性转化和迁移性是肝癌浸润和转移的基础，同时胆管反应又为肝癌的发生发展提供基质微环境。本文就胆管反应的分类、细胞多样性以及胆管反应在肝炎和肝癌发生发展中的作用研究进展进行综述，旨在研究胆管反应对阐明肝癌的发病机制，探索有效的治疗手段。
Ductular reaction （DR） is a phenomenon that refers to impaired hepatocellular proliferation and activated hepatic stem cells at times of demand such as hepatic re generation. The components of ductular reactions are thought to be derived from activated hepatic progenitor cells, intermediate hepatobiliary cells, and reactive ductular cells. DRs are thought to play two roles in hepatocarcinogenesis： their hepatic progenitor cells may undergo malignant trans formation and migration, and they may contribute to the de velopment of the tumor＇s microenvironment. Exploring DR phenotype, cellular diversity, and relationship to hepatocar cinogenesis will further enhance our understanding of the pathogenesis of human hepatocellular carcinoma with an ultimate goal of developing new therapies.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2013年第9期716-719,共4页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金重点项目（81030041）
关键词
胆管反应
肝祖细胞
中间型肝胆细胞
肝癌微环境
Ductular reaction
Hepatic progenitor cell
Intermediate hepatobiliary cell
Microenvironment of hepatocellular carcinoma
