摘要
目的:研究介入治疗前后宫颈癌组织内肿瘤细胞和淋巴细胞Fas/FasL的动态变化,对介入治疗前后癌组织局部细胞免疫功能的动态变化进行初步探究。方法:对21例宫颈癌介入治疗前后标本,采用免疫组化法检测Fas和FasL的表达率及表达强度。结果:介入前、介入后第7天和介入后第14天3个时间点两两之间的比较:除了介入前与介入后第14天相比两种细胞Fas和FasL表达率差异无显著性(P>0.05),介入后第7天和第14天时FasL淋巴细胞表达率差异无显著性(P>0.05),其他均有统计学意义。结论:介入治疗能有效地逆转癌组织局部肿瘤细胞和淋巴细胞Fas/FasL系统的表达,促进肿瘤细胞死亡。
Objective：To evaluate the effects of interventional arterial chemotherapy, through the variation of expressions of Fas and FasL in malignant cells and lymphocytes of cervical cancer after the therapy. Methods： Expressions of Fas and FasL in 21 cases with cervical cancer before-and after-interventional therapy （on the 7th and 14th day） were determined by S-P Jmmunohistochemical staining. Results： Before interventional therapy, the positive rates of Fas and FasL expression in lymphocytes were 38.10% and 4.76%;that of malignant cells were 19.05% and 47.62%.At the 7th day of post-therapy, the expression rates of Fas and Fast. in lyrrphocytes were 85.71% and 38.10% ;that of malignant cells were 100% and 85.71%. Compare to baseline, the difference was significant （P〈 0.05）. At the 14th day, the expression rotes of Fas and FasL of lyrrphocytes were 33.33% and 14.29% ;that of rnalignant cells were 19.05% and 47.62%（P〈0.05） .The difference was no significant when compare to baseline before the therapy（ P 〉 0.05） ;The difference was signlficant when compare to the 7th day（ P 〈 0. 05）. Conclusions： The Fas/FasL system in the cancer tissue was enhanced by the interventional therapy that induced tumor cell death.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第8期472-474,共3页
Journal of Practical Obstetrics and Gynecology
