糖尿病周围神经病变的诊治进展被引量：56

Progress in the diagnosis and treatment of diabetic peripheral neuropathy

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摘要糖尿病周围神经病变(DPN)是糖尿病主要慢性并发症之一,严重影响患者的生活质量。早期诊断及治疗是降低DPN、提高患者生活质量的关键。目前使用的诊断方法中,问卷调查法简单易行,非侵入性检查法研究与使用日益广泛,有创检查方法不断完善,而对生物标志物的检测正在探索中。对DPN的治疗除控制血糖,尚无其他有效对因治疗方法,新近研究主要集中在镇痛药物和抗氧化应激治疗领域,其他药物及非药物性治疗尚缺乏大样本研究。基因治疗及干细胞治疗正在探索中。今后的研究方向可能重在于加深发病机制的认识以促进新药研发,以及药物合理联合应用优化治疗策略。 Diabetic perlpherat neuropathy （DPN） is one of the most severe diabetic chroniccomplications. Early diagnosis and treatment play a key role in reducing the degree of disability and improving the life quality of the patients. Among the currently used diagnostic methods, questionnaire method is simple and non-invasive inspection methods are extensively studied and used;invasive inspection methods are improved continuously, and the detection of biomarkers is being explored as well. At present, there is no effective etiological treatment, except the glycemic control, in the treatment of DPN. Current researches mainly focus on the development of analgesic drugs and antioxidants. Gene and stem cell therapies are being explored. The direction of studies from now on is to deepen the comprehension of pathogenesis of this disease to develop the new drugs and optimize the treatment strategy in combination use of drugs.

作者李颖李刚冯波

机构地区同济大学附属东方医院神经内科同济大学附属东方医院内分泌科

出处《中国糖尿病杂志》 CAS CSCD 北大核心 2013年第9期769-772,共4页 Chinese Journal of Diabetes

关键词糖尿病周围神经病变诊断治疗 Diabetic peripheral neuropathy （DPN） Diagnosis Treatment

分类号 R587.2 [医药卫生—内分泌]

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