摘要
目的:探讨"黑质-丘脑-皮层"神经通路在运动疲劳发生、发展中的调控作用。方法:采用局部场电(LFPs)及皮层脑电(ECoG)同步记录技术,对一次性力竭运动中大鼠黑质网状部(SNr)、丘脑腹外侧核(VL)及皮层辅助运动区(SMA)神经元电活动变化进行同步、动态观察。结果:在力竭运动的不同阶段"黑质-丘脑-皮层"通路神经元电活动出现明显的阶段性变化特征:自主运动期黑质网状部神经元电活动频率减小,振幅增大,δ、θ波活动显著增强,兴奋性下降;丘脑腹外侧核和皮层神经元电活动频率增大,振幅减小,α波活动显著增强,兴奋性升高;疲劳初期和力竭期时,黑质网状部神经元电活动频率增大,振幅减小,α波活动显著增强,兴奋性升高,丘脑腹外侧核和皮层神经元电活动频率减小,振幅增大,δ、θ波活动显著增强,兴奋性下降。力竭运动中皮层与丘脑腹外侧核电活动变化趋势相同,但与黑质网状部相反。结论:大鼠力竭时,黑质网状部神经元兴奋性增强,抑制了丘脑腹外侧核神经元的兴奋性,进而对运动皮层产生去兴奋作用。"黑质-丘脑-皮层"通路功能失调是导致力竭及运动能力下降的重要因素之一。
Objective： It is to observe the modulatory effect of ＇ SNr- VL-SMA＇ pathway during the exhaustive exercises. Methods： The dynamic changes of neural activity in SNr, VL and SMA were simultaneously recorded through the LFPs and ECoG recording techniques. Results： The neural activity of the ＇SNr-VL-SMA＇ pathway showed dear stage features： during the automatic period, dominant frequency of SNr activity decreased, while the amplitude of the activity and power of δ and θ band increased significantly, which implies the decrease of neural activity; meanwhile in VL and SMA, the dominant frequency increased and the amplitude decreased; thepower of of band increased significantly and the neural activity increased. At the beginning of the fatigue period and exhaustive stage, the dominant frequency of SNr increased and the amplitude decreased; the power of a band increased significantly and the neural activity increased. In VL and SMA, the amplitude and β and θ power increased while the neural activity and dominant frequency degreased. In general, the neural activity of SMA and VL changed in the same way, but in a contrary way with SNr. Conclusions： The increased neural activity in SNr depressed the VL activity, and thus inhibited the neural activity in SMA. The dysfunction of the ＇ SNr-VL-SMA＇ pathway might be one of the important factors resulting in fatigue and decrease of the exercise capacity.
出处
《上海体育学院学报》
CSSCI
北大核心
2013年第5期57-62,共6页
Journal of Shanghai University of Sport
基金
国家自然科学基金资助项目(31171138)
全国教育科学"十一五"规划重点课题(DLA080119)
