摘要
近年来，我国发酵类制药行业发展迅速，目前抗生素产量已居世界第一位。抗生素菌渣是抗生素发酵工业中的主要固体废弃物，其主要成分包括抗生素菌丝体、剩余培养基成分、发酵中微生物代谢产物及少量的残留抗生素等，由于菌渣对人体及环境产生潜在的耐药性风险，依据2008年修订的《国家危险废物名录》，
Microwave radiation was used to break ceil wall of penicillium fermentation residue. By measuring the changes of protein and polysaccharide content in the supernatant after centrifugation, the effect of different loading time, loading power and initial moisture content of the residue on wall breaking and dewatering performance was investigated. Orthogonal experiment was used to confirm the best loading condition. The results showed that microwave radiation could obviously break the cell wall and improve dewatering performance of the residue. For the penicillium residue with a moisture content of 90 %, after radiation of 414 W for 120 s, the content of protein and polysaccharide increased from 110.25 μg · ml^-1 and 28.20 μg · ml^-1to 265.76 μg · ml^-1 and 93.52 μg · ml^-1 respectively, and moisture decreased from 83.75% to 75.26%. The best loading condition by orthogonal experiment was that penicillium residue with an initial moisture of 90% could reach the best wail-breaking effect after radiation of 414 W for 120 s.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2013年第10期3812-3817,共6页
CIESC Journal
基金
国家公益性行业科研专项(201209024)~~
关键词
青霉素菌渣
微波辐射
蛋白质
多糖
正交试验
破壁
penicillium fermentation residue
microwave radiation
protein
polysaccharides
orthogonaltest
cell wall breaking
