摘要
对人与动物RNA病毒的基因组准种多样性的研究进展作了简单综述,特别详细概述了在体外模型中对我国常见4种动物RNA病毒与病毒中和反应密切相关的蛋白基因在抗体免疫选择压作用下演化规律的研究进展,还就病毒在免疫选择压下演变规律的研究对动物疫病防控的指导意义作了讨论,也对病毒准种多样性的深入研究提出了展望。
Progresses in genome quasispecies multiplicity of human and animal RNA viruses were reviewed, and especially recent studies in evolution of common animal RNA viruses in their viral neutralization-related protein genes under the selective pressure of antibody immunity in the in vitro models were described. Possible influence of virus evolution under immune selective pressure on prevention and control of animal viral diseases was discussed, and the futher studies on viral quasispecies multiplicity were suggested.
出处
《生命科学》
CSCD
2013年第9期843-852,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金面上项目(30270060
30-671571)
农业公益性行业科研专项经费项目(20-0803019)
关键词
动物RNA病毒
准种
免疫选择
animal RNA viruses
quasispecies
immune selection
