摘要
目的:探讨齐拉西酮合并小剂量丙戊酸钠治疗女性难治性精神分裂症的临床疗效观察及护理。方法:将90例女性难治性精神分裂症患者随机分为两组,每组各45例,治疗组予齐拉西酮合并小剂量丙戊酸钠治疗,对照组予氯氮平治疗,疗程均为12周。用阳性与阴性症状评定量表(PANSS)评定临床疗效、护士用简明精神病量表(N-BPRS)评定护理效果及症状量表(TESS)评定药物不良反应。于治疗前、治疗后1、2、4、8、12周末各评定1次。结果:治疗组总有效率为84.4%,对照组总有效率为74.4%,两组对比有显著性差异(P<0.05),N-BPRS显示治疗组症状控制快,疗效好,治疗组的不良反应比对照组少且轻。结论:齐拉西酮合并小剂量丙戊酸钠治疗女性难治性精神分裂症临床疗效显著,安全性高,使护理工作量明显减轻,提高了整体护理质量。
Objective ：To investigate the combined low - dose valproate ziprasidone treatment of female refractory schizophrenia clinical observation and nursing. Methods ：90 female patients with refractory schizophrenia were randomly divided into two groups, each 45 cases, combined treatment group to a small dose of valproate ziprasidone treatment, the control group were given clozapine treatment regimens for the 12 weeks. With positive and negative symptoms rating scale （ PAN- SS） assessed the clinical efficacy, nurses Brief Psychiatric Rating Scale （ N - BPRS） assessed care effects and symptoms scale （TESS） assess adverse drug reactions. Before treatment, after treatment, 1,2,4,8,12 evaluated once each weekend. Results：The total effective rate was 84. 4% in the control group, the total effective rate was 74. 4%, compared with the two groups was significant difference （ P 〈 0. 05 ）, N - BPRS display of symptom control fast, effective, treatment of adverse reactions less than the control group and light. Conclusions ：Ziprasidone combined low -dose valproate treatment of female refractory schizophrenia significant clinical efficacy, safety, significantly reduce the nursing workload and im- prove the overall quality of care.
出处
《航空航天医学杂志》
2013年第9期1133-1135,共3页
Journal of Aerospace medicine
