摘要
目的观察血液透析患者血管钙化的发生情况,探讨血清骨钙素水平与血管钙化的关系。方法采用酶联免疫吸附法测定血清骨钙素水平;X线片检测腹主动脉、股动脉及桡动脉部位血管钙化,计算血管钙化积分;检测患者的一般生化指标;对各参数的相互关系进行统计分析。结果入选30例血液透析患者及15例健康对照者,X线片显示血液透析患者中19例(63.3%)有不同程度、不同部位的血管钙化。轻度钙化11例(占发生钙化人数的57.9%),中度钙化5例(占发生钙化人数的26.3%),重度钙化3例(占发生钙化人数的15.8%),正常对照组无人发生血管钙化。有血管钙化者血清骨钙素水平明显高于无血管钙化者(P<0.05);中、重度血管钙化的血液透析患者血清骨钙素水平明显高于无钙化或轻度钙化患者(P<0.05)。多元线性回归分析显示血清骨钙素水平是血管钙化积分的独立影响因素。结论血液透析患者普遍存在血管钙化,血清骨钙素水平是血管钙化的独立影响因素。
Objective To observe vascular calcification and to investigate the relationship between osteocalcin level and vascular calcification in hemodialysis（HD） patients.Methods The levels of serum osteocalcin from 30 HD patients were measured by ELISA.The vascular calcification was detected by plain radiographs.Interrelations among above parameters were examined statistically.Results Vascular calcification on X-ray films presented in 19 cases （63.3%）.Of these 19 cases,11 cases were found have mild degree of calcification,5 cases were found have moderate degree of calcification,and 3 cases were found have severe degree of calcification.Serum osteocalcin was higher in hemodialysis patients with vascular calcification than patients without vascular calcification （P 〈 0.05）.Lower osteocalcin was frequently seen in patients with mild vascular calcification than moderate to severe vascular calcification （P 〈 0.05）.Serum osteocalcin concentration was the independent factor affecting score of vascular calcification.Conclusion Vascular calcification is commonly present in hemodialysis patients.Serum osteocalcin level was the independent factors affecting score of vascular calcification.
出处
《医学研究杂志》
2013年第9期67-69,共3页
Journal of Medical Research
基金
湖北省卫生厅青年科技人才基金资助项目(QJX2012-41)
关键词
血液透析
血管钙化
X线片
骨钙素
Hemodialysis
Vascular calcification
X - ray film
Osteocalcin
