摘要
目的分析成人隐匿性自身免疫性糖尿病(Latent Autoimmune Diabetes in Adults,LADA)患者骨密度(Bone Mineral Density,BMD)变化,并探讨其相关影响因素。方法筛选196例LADA患者,其中未继发骨质疏松患者98例(A组)、继发骨质疏松患者98例(B组),比较2组患者腰椎2-4(L2-4)、股骨颈、全身的BMD;测定B组患者的糖化血红蛋白(Glycated Hemoglobin,Hb A1c)、血清钙(Serum Calcium,Ca)、血清磷(Blood Phosphorus,P)、碱性磷酸酶(Alkaline Phosphatase,ALP)、身体质量指数(Body Mass Index,BMI)、空腹血浆胰岛素(Fasting Plasma Insulin,FPI),分析上述指标与LADA患者继发骨质疏松的相关性。结果 B组患者L2-4、股骨颈、全身BMD均小于A组,差异有统计学意义(P<0.05);年龄、病程、空腹血浆胰岛素是LADA患者继发骨质疏松的影响因素(均P<0.05);多元Logistic回归分析显示,病程≥8Y、FPI<1.05μU/m L、年龄≥55岁是LADA患者继发骨质疏松的危险因素(均P<0.05)。结论随着年龄增加、病程延长和空腹血浆胰岛素水平升高,LADA患者继发骨质疏松的概率也大大提高。
Objective To examine the changes of bone mineral density（ BMD） in patients with latent autoimmune diabetes in adults（ LADA） and to determine the influential factors. Method 196 patients with LADA were selected. Ninety-eight patients without osteoporosis were selected as group A and 98 patients with secondary osteoporosis as group B. The lumbar 2-4（ L2-4） femoral neck,body bone density,and BMD of the two groups were compared. The serum glycated hemoglobin（ Hb A1 c）,serum calcium（ Ca）,serum phosphorus（ P）,alkaline phosphatase（ ALP）,body mass index（ BMI） and fasting plasma insulin（ FPI） of group B were then measured. The correlation of these indexes to the secondary osteoporosis in LADA patients was then determined. Findings Group B＇s L2-4,the femoral neck,the body was less than that of group A. The difference was statistically significant（ P0. 05）. Age,disease duration,fasting plasma insulin（ P0. 05） are the influential factors that give rise tosecondary osteoporosisin LADA patients.Multivariate logistic regression analysis showed that the duration of disease ≥8 Y,FPI 1.05μU/m L,age ≥55 years was a risk factor of secondary osteoporosis in LADA patients（ P〈0. 05）. Conclusion As age increases,the duration of the disease increases and the fasting plasma insulin levels increase,and the probability of secondary osteoporosis in LADA patients will also be greatly enhanced. It is suggested that LADA patients should be actively intervened to prevent osteoporosis.
出处
《健康研究》
CAS
2017年第5期488-490,共3页
Health Research
