摘要
目的:探讨眼表化学伤患者泪液中炎症介质TNF-α,IL-1β和IL-6浓度变化与眼表化学伤病情轻重及预后的相关性。方法:眼表化学伤患者66例80眼,按Roper-Hall标准分度将眼表化学伤分为4度,其中Ⅰ和Ⅱ度35例44眼,Ⅲ度22例25眼、Ⅳ度9例11眼,采用双抗体夹心酶联免疫吸附法(ELISA)测定泪液中TNF-α,IL-1β和IL-6的浓度,并以12例健康成年人作为对照。结果:眼表化学伤组TNF-α,IL-1β和IL-6水平均高于对照组(P<0.01);眼表化学伤患者中Ⅳ度组>Ⅲ度组>Ⅰ和Ⅱ度组(P<0.01);Ⅳ度组致盲率高于Ⅲ组和Ⅰ,Ⅱ组(P<0.05)。结论:眼表化学伤患者TNF-α,IL-1β和IL-6水平明显升高,且随着Roper-Hall标准分度增高而增高。TNF-α,IL-1β和IL-6水平越高,致盲率则越高。炎症细胞因子水平对判断眼表化学伤患者病情严重程度及预后有重要意义。
AIM： To explore the correlation of inflammatory cytokine（TNF-α IL-1β IL-6） concentrations of patients＇ tears with chemical burns of the ocular surface and its severity and prognosis. METHODS： Totally, 66 cases （80 eyes） of chemical burns of the ocular surface were divided to 4 degrees according to Roper-Hall classificatory criteria, with 35 cases （44 eyes） of degree I and II, 22 cases （25 eyes） of degree Ill, 9 cases （11 eyes） of degree IV. The concentration of TNF-a, IL-113 and IL-6 in tears was detected by ELISA, and there were 12 healthy people as control group. RESULTS： The concentration of TNF-α IL-1β IL-6 in patients with chemical burns of the ocular surface was higher than control group （ P〈 0. 01 ）, among which, degree IV 〉 degree III 〉 degree I and II （P〈0.01）, and blinding rate in degree IV was higher than that in degree III, I and II （P〈0.05）. CONCLUSION： The concentration ofTNF-α IL-1β IL-6 in patients with chemical burns of the ocular surface rises dramatically, with the increase of Roper Hallclassificatory criteria. With the increase of concentration of TNF-α IL-1β IL-6, the blinding rate rises. There would be of great significance of inflammatory cytokine concentrations for judging the severity and prognosis of patients with chemical burns of ocular burn.
出处
《国际眼科杂志》
CAS
2013年第10期2146-2148,共3页
International Eye Science
