摘要
目的 探讨血清肿瘤坏死因子 -α(TNF -α)在老年高血压病 (EH)患者血清中含量变化及其意义。方法 通过酶标双抗体夹心法测定 5 3例EH患者和 32例健康老人血清TNF -α水平。结果 EH患者血清中TNF -α活性早期即明显升高 (与对照组比较P <0 0 1) ,Ⅱ期及Ⅲ期进一步升高 (与Ⅰ期比较均P <0 0 1) ,但Ⅱ期与Ⅲ期间差异无显著性(P >0 0 5 )。结论 血清TNF -α参与高血压病的发生发展过程 。
Objective To investigate the significance of change in serum TNF-α in elder hypertensive (EH) patients. Methods Serum TNF-α in 53 cases of EH and 32 cases of healthy elderly, was measured by using ELISA.Results TNF-α rose in early stage of EH( P <0 01, compared to control group) and continued to rise in stage Ⅱ or Ⅲ ( P <0 01, compared to stage Ⅰ). Howerer there is no significant difference between stage Ⅱ and Ⅲ. Conclusion Serum TNF-α may be involved in the occurance and development of hypertension, and corralate with other pathophysiological changes.
出处
《广东医学》
CAS
CSCD
2000年第11期930-931,共2页
Guangdong Medical Journal
基金
广东省医学科研基金资助课题!(编号 :B1 9971 4 2 )
