摘要
儿童慢性肾脏疾病(chronickidneydisease,CKD)是威胁儿童正常生长发育的主要疾病之一,在我国主要病因以肾小球疾病为主,常并发心血管疾病、肾性贫血、肾性骨病等,严重影响儿童生活质量。CKD患儿由于肾脏病变25-羟维生素D[25.(OH)VitD]羟化受到影响、尿毒症导致的皮肤变化使骨化三醇合成减少等因素常引起25-(OH)VitD水平低下。该文就CKD患儿25-(OH)VitD基础水平和影响因素作一综述。
Chronic kidney disease (CKD) is a disease that grately threaten the health of children. In China the main cause of CKD in children is glomerular disease. CKD usually supervene cardiovascular diseases, renal anemia, renal osteodystrophy, and affect the life quality of children greatly. In CKD patients, the hydroxyl- at.ion of 25 (OH) Vitamin D is disordered, and the endogenous synthesis of calcitriol decreased,leading to the re- duce of 25 (OH) Vitamin D. This article will summarize the present researches about the level of 25 (OH) Vita- min D in CKD children in order to provide guidance for the treatment of CKD with Vitamin D.
出处
《国际儿科学杂志》
2013年第5期470-473,共4页
International Journal of Pediatrics
基金
基金项目:甘肃省中药管理局基金项目(GZK-2011-23)