摘要
哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）是一种进化上十分保守的蛋白激酶，催化特定的底物来调节蛋白翻译、细胞生长、增殖、自噬等基本生理活动，在肿瘤、糖尿病、多种肾脏病中起重要调节作用。多数肾小球疾病由足细胞损伤、滤过屏障受损引起。已有研究证实mTOR与足细胞损伤有关，但具体调节机制尚不明确。该文对mTOR激酶的调节机制以及在肾小球疾病发生发展中的作用进行综述，为认识肾小球疾病的发病机制提供新的思路。
] The mammalian target of rapamycin （mTOR） is a evolutionary conserved serine/threonine kinase that catalytics specific substrates and.regulates cellular basic physiological events, such as growth, prolifer- ation, autophagy and protein translation. It plays an important role in the regulation of cancer, diabetes and a vari- ety of kidney diseases. Most of glomerular diseases ~e resulted from the podocytes and filtration barrier damage. Studies have suggested that there is a close relationship between mTOR and podosytes damage, but specific mechanism of regulation is not clear now. This review discusses the regulatory mechanism of roTOR kinase and its role in the glomerular disease to provide new ideas for understanding of glomerular disease pathogenesis.
出处
《国际儿科学杂志》
2012年第6期602-605,共4页
International Journal of Pediatrics
