摘要
目的探讨功能磁共振（fMRI）、磁共振弥散张量成像（DTI）、神经导航、术中超声（IOUS）、皮层脑电监测（ECoG）等对功能区附近以癫痫为主要症状的低级别胶质瘤手术治疗的指导意义。方法回顾性分析2009～2010年重庆医科大学附属第一医院神经外科患者23例，术前fMRI、DTI明确病灶与传导束、功能区的位置关系，电生理、影像学检查定位致痫灶及病灶，采用M RI介导的神经导航系统制订手术计划，选择最佳手术入路，术中利用超声实时监测精确定位病灶范围，确定切除程度，术中ECoG定位致痫灶，手术显微镜下避开功能区处理病灶及致痫灶，术后详细评估记录患者预后等。结果 fMRI、DTI、神经导航、超声、EC o G等精确定位病灶及致痫灶，显微镜、术中病理指导下病灶切除程度：Ⅰ～Ⅱ级17例，Ⅲ级4例，Ⅳ～Ⅴ级2例。术后运动性失语1例，偏瘫、单瘫4例，意识障碍1例，经神经营养、脱水、高压氧等治疗均好转康复出院，无死亡病例。生活质量评估：Ⅰ～Ⅱ级20例，Ⅲ级3例，无Ⅳ级植物生存病例。切除临床疗效评价：治愈20例，好转3例，无如故或恶化病例。术后随访6～24个月，根据Engel癫痫疗效分级评估：Ⅰ～Ⅱ级21例，Ⅲ级2例，无Ⅳ级病例。结论 fMRI、DTI、神经导航、超声、ECoG等指导功能区附近低级别胶质瘤手术，最大限度切除病灶、同时处理致痫灶，能够有效保护功能区神经功能，大大减少对功能区正常脑组织副损伤，同时提高了症状性癫痫疗效。
Objective To explore the guidance significance of the functional MRI and DTI （fMRI ,DTI） ,intraoperative ultra-sound（IOUS） ,neuronavigation ,electrocorticography（EcoG） monitoring used in surgical treatment of low-grade gliomas with epi-lepsy as main symptom located near the eloquent brain regions .Methods 23 neurosurgical patients in the First Affiliated Hospital of Chongqing Medical University during 2009-2010 were performed the retrospective analysis .The preoperative fMRI ,DTI deter-mined the positional relation between the lesions with the conduction bundle and the eloquent brain regions ,the electrophysiological and imageological examinations positioned the epileptogenic focus and lesions ,the MRI-mediated neuronavigation system was adopt-ed to formulate the surgical plan and choose the best surgical approach ,IOUS was used to perform the realtime monitoring for pre-cisely positioning the lesion range and determining the extent of resection ,and the intraoperative EcoG was adopted to determine the epileptogenic focus localization ,the lesions and the epileptogenic focus was dealed by the operating microscope for avoiding the func-tional region ,and the patient′s prognosis was evaluated and recored in detail after operation .Results By the precisely positioning the lesions and epileptogenic focus by fMRI ,DTI ,neuronavigation and ultrasound ,the lesion resection degrees by the operative mi-croscope and intraopertaive pathological guidance were 17 cases of Ⅰ-Ⅱ grade ,4 cases of Ⅲ grade and 2 case of Ⅳ-Ⅴ grade .1 case of motor aphasia ,4 cases of hemiplegia and monoplegia and 1 case of disturbance of consciousness after operation were improved by the treatment of neurotrophy ,dehydration and hyperbaric oxygen and discharged from hospital with rehabilitation .No death case occurred .The evaluation of the life quality ：20 cases ofⅠ-Ⅱ grade ,3 cases of Ⅲ grade and no vegetable survival case of Ⅳ grade . The evaluation of resection clinical effect ：20 cases of cure ,3 cases of improvement ,no case of as before and exacerbation .After fol-lowed up for 6-24 months ,according to Engel classification of seizure efficacy assessment ：Ⅰ-Ⅱ grade in 21 cases ,Ⅲ grade in 2 case ,no case of Ⅳgrade .Conclusion fMRI ,DTI ,neuronavigation ,IOUS and EcoG for guiding the operation of low grade gliomas located near the eloquent brain regions can resect the lesion to the largest extent and simultaneously deal with epileptogenic focus , effectively protect the neurological function of the functional region ,greatly reduce the side-injury of the normal brain tissues in the functional region ,at the same time increase the curative effect of symptomatic epilepsy .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第27期3239-3241,共3页
Chongqing medicine
关键词
神经胶质瘤
癫痫
磁共振成像
超声检查
glioma
epilepsy
magnetic resonance imaging
ultrasonography
