摘要
酰胺质子转移成像(ATP)是一种新的由化学饱和交换位移成像(CEST)发展而来的通过检测体内游离蛋白质或多肽中酰胺质子与水中的氢质子之间交换速率从而反映体内游离蛋白质含量及pH值变化的成像方式,能够在脑肿瘤、脑卒中、神经退行性疾病及儿童脑发育中提供重要的影像学信息,为临床的诊断、治疗及预后方面提供帮助。本文主要阐述APT成像方式在脑疾病当中的研究进展。
Amide proton transfer(APT)imaging is a new imaging method developed by chemical exchange saturation transfer(CEST)imaging.APT could detect the exchange rate between amide protons in free proteins or peptides and water protons,and reflect the changes of free protein content and pH value.It can provide important imaging information in brain tumors,stroke,neurodegenerative diseases and children's brain development and help for their clinical diagnosis,treatment and prognosis.The research progress of APT imaging in brain diseases is reviewed in this paper.
作者
魏平(综述)
李传亭(审校)
WEI Ping;LI Chuanting(Shandong Medical Imaging Research Institute, Affiliated to Shandong University, Jinan 250021, P.R.China)
出处
《医学影像学杂志》
2020年第3期496-499,共4页
Journal of Medical Imaging
基金
山东省医药卫生科技发展计划项目(编号:2015WS0179)。
关键词
酰胺质子转移成像
磁共振成像
脑肿瘤
脑卒中
神经退行性疾病
脑发育
Amide proton transfer imaging
Magnetic resonance imaging
Brain tumor
Stroke
Neurodegenerative disease
Brain development
