摘要
目的探讨老年女性2型糖尿病(T2DM)患者皮质醇变化及其与糖代谢、相关生化指标的关系。方法 80例老年女性T2DM患者为病例组,正常值为对照组;80例按照糖化血红蛋白(HbA1c)分组:HbA1c>7%组40例,年龄(67.44±6.270)岁;HbA1c≤7%组40例,年龄(67.05±5.54)岁,分析皮质醇变化。结果病例组血浆皮质醇与对照组比较明显增高(P<0.05);HbA1c>7%组日均血浆皮质醇、24 h尿游离皮质醇、空腹血糖(FPG)明显高于HbA1c≤7%组(P<0.05);老年女性T2DM患者皮质醇与FPG、HbA1c、总蛋白呈正相关(P<0.05)。结论老年女性T2DM患者皮质醇明显增高,血糖升高与皮质醇互为因果,良好控制血糖、监测皮质醇可以改善老年女性T2DM患者病情。
Objective To discuss the change of cortisol in elderly female patients with type 2 diabetes mellitus （T2DM） and the relationship between glucose metabolism and related biochemical. Methods 80 cases of elderly female patients with T2DM were collected,and the patients were divided into two groups according to the glycosylated hemoglobin （HbA1c） ： HbA1c〉 7% group （n = 40）, age （67.44 ±6.27） ;HbA1c ≤7% group （n =40） ,age（67.05±5.54）. The changes of cortisol were analyzed. Results The plasma cortisol were significantly higher in ease group than those in control group （P 〈0.05 ）. Daily average of blood plasma cortisol,24h urine free cortisol, FPG were significantly higher in HbA1c 〉 7% group than those in HbA1c ≤7% group （P 〈 0.05 ）, Elderly women patients with T2DM cortisol and FPG, HbA1c, and total protein were positively correlated （P 〈 0.05 ）. Conclusion This study shows that plasma cortisol in elderly women patients with T2DM are significantly higher,blood glucose and cortisol are as both cause and effect,good blood glucose control, monitoring of cortisol can improve the condition of elderly women patients with T2DM.
出处
《宁夏医学杂志》
CAS
2013年第9期833-834,共2页
Ningxia Medical Journal
关键词
老年女性
2型糖尿病
皮质醇
Elderly women
Type 2 diabetes mellitus
Cortisol
