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吡格列酮对2型糖尿病大血管病变的保护作用

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摘要 目的:观察吡格列酮治疗前后2型糖尿病患者颈动脉内膜中层厚度(IMT)、C反应蛋白(C-RP)、一氧化氮(NO、一氧化氮合酶(NOS)水平的变化。方法:将60例2型糖尿病患者采用随机、双盲、安慰剂、平行对照法,分成安慰剂组28例,治疗组32例,均给予诺和龙和或二甲双胍降糖治疗,治疗组给予吡格列酮15～30mg日一次餐前口服,治疗6个月。结果:治疗组血糖、C-RP水平明显下降(P<0.01),NO、NOS水平明显提高(P<0.01),颈动脉内膜中层厚度明显减轻(P<0.01)。结论:吡格列酮治疗2型糖尿病,除改善胰岛素抵抗,降低血糖外,还有明显抗炎症,改善血管内皮功能,缓解动脉硬化的作用。
作者 庞建伟 孙舒岩 李宏 姜振环 崔红
机构地区 佳木斯大学附属第一医院
出处 《黑龙江医药科学》 2013年第4期50-50,52,共2页 Heilongjiang Medicine and Pharmacy
关键词 吡格列酮 糖尿病 C反应蛋白 一氧化氮
分类号 R587.1 [医药卫生—内分泌] R969 [医药卫生—药理学]
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参考文献9

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二级参考文献4

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黑龙江医药科学
2013年 第4期

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