摘要
目的:探讨珍菊降压片联合氨氯地平片对肾性高血压大鼠(RHR)血压、心肌重构和内皮功能的影响。方法:建立两肾一夹RHR模型,给予RHR灌服珍菊降压片及氨氯地平片4周,尾袖法测量大鼠尾动脉收缩压及测定左室重量指数(LVWI),应用放射免疫法及硝酸还原酶法检测RHR心肌内皮素-1(ET-1)和一氧化氮(NO)水平。结果:珍菊降压片联合氨氯地平片降压效果良好,且能明显升高RHR的NO水平及降低ET-1及LVWI。结论:珍菊降压片联合氨氯地平片较单用氨氯地平片可以明显升高NO水平,降低ET-1、LVWI,更好的控制RHR血压及保护心肌。
Objective： To study Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure and Myocardial Remodeling and endothelial function in renal hypertensive rat（RHR）.Methods： The two-kidney and one-clip rat method was established.The tail artery blood pressure and LVWI and endothelin,nitric oxide level in myocardium were measured after administration with Zhenjvjiangya tablet and Amlodipine tablet.Results： Effect of Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure is remarkable,and can increase the nitri coxide level and decrease endothelin and LVWI.Conclusion： Zhenjvjiangya tablet combined with Amlodipine tablet can obviously reduce the blood pressure,increas the nitric oxide level and decrease endothelin to protect myocardium.
出处
《中国医药导刊》
2013年第7期1249-1250,共2页
Chinese Journal of Medicinal Guide
基金
沧州市科技局立项课题(编号:08ZD247)
关键词
高血压
内皮素
一氧化氮
心肌重构
珍菊降压片
氨氯地平片
Hypertension
Endothelin-1
Nitric oxide
Myocardial Remodeling
Zhenjujiangya Tablet
Amlodipine tablet
