摘要
目的 检测胆管良、恶性疾病患者的血清IL 6水平 ,探讨胆管癌和胆管良性疾病的鉴别以及与肿瘤负荷的相关性。方法 采用ELISA双抗体夹心法测定 30例胆管良性疾病患者 ,2 5例胆管癌患者和 2 0例健康者的血清IL 6水平 ,并对胆管癌患者手术前后血清IL 6的水平变化进行观察。结果 2 5例胆管癌患者血清IL 6水平明显高于胆管良性疾病及健康者 (P <0 0 5 ) ,胆管癌手术后血清IL 6水平明显低于手术前 ,差异有显著意义 (P <0 0 5 )。结论 胆管癌患者血清IL 6水平明显增高 ,检测血清IL 6可做为诊断胆管癌的重要指标。
Objective The purpose of this study was to measure the IL 6 serum level in patients with cholangiocinoma and benign biliary disease, and to evaluate the role of IL 6 level in the diagnosis of cholangiocacinoma, benign biliary disease as well as a measurement of tumor burden.Method Serum IL 6 level was measured by ELSA method in 25 patients of choangiocarcinoma, 30 patients of benign biliary disease and 20 normal controls. The changes of IL 6 serum level after cholangiocacinoma resection were investigated.Result The levels of serum IL 6 were higher in cholangiocacinoma than in benign biliary disease and nomal controls ( P <0 05). High IL 6 level was more often seen preoperatively than postoperatively in cases of cholangiocacinoma.Conclusion Serum IL 6 levels correlate with the status of cholangiocarcinoma and tumor burden. IL 6 level could be used as an important parameter for clinical evaluation in patients of cholangiocarcinoma.
出处
《中华普通外科杂志》
CSCD
2000年第10期585-586,共2页
Chinese Journal of General Surgery
