摘要
目的:检测胆管癌患者血清IL-6和粘附分子P-选择素(P-sel)、细胞间粘附分子-1(1CAM-1)的水平,并探讨其临床意义。方法:采用ELISA法检测39例胆管癌患者、33例良性胆管疾病患者和30例正常人血清IL-6、P-sel和ICAM-1水平。结果:胆管癌患者血清IL-6、P-sel和ICAM-1水平均显著高于良性胆管疾病患者和正常入,且IL-6的水平与P-selI、CAM-1呈正相关,但高分化胆管腺癌与中分化胆管腺癌患者比较三项指标均无显著性差异;良性胆管疾病患者血清IL-6、P-sel和ICAM-1水平有所升高,与正常人比较差异有显著性。结论:胆管癌患者血清IL-6、P-sel和ICAM-1水平显著升高,提示粘附分子在胆管癌发病中可能起一定作用,检测P-sel和ICAM-1对胆管癌的辅助诊断具有重要意义。
Objective： To detect IL-6, P-selectin （P-sel） ahd intercellular adhesion molecule-1 in sera of the patients with cholangiocarcinoma, and to study their clinical significance. Methods ： The concentration of IL-6, P-sel and ICAM-1 in sera of 39 patients with cholangiocarcinoma, 33 patients with benign lesion in biliary ducts and 30 normal volunteer were detected by ELISA. Results： The concentration of IL-6, P-sel and ICAM-1 in sera of the patientes with cholangiocarcinoma were obviously higher than that in the patientes with benign lesion inbiliary ducts and in normal volunteer, meanwhile the level of IL-6 was correlated to P-sel and ICAM-1 positively, but there were no difference of the concentration of 1L-6, P-sel and ICAM-1 between the patientes with well-differentiated bile duct adenocarcinoma and moderately differentiated bile duct adenocarcinoma. The concentration of IL-6, P-sel and ICAM-1 in sera of the pa tientes with benign lesion in biliary ducts were higher than that in normal volunteer. Conclusion ： The concentration of IL-6, P-sel and ICAM-1 in sera of the patientes with cholangiocarcinoma were elevated, which indicated that P-sel and ICAM-1 play a role in cholangiocarcinoma and the detection of P-sel and ICAM-1 might be a useful tool in auxiliary diagnosis of cholangiocarcinoma.
出处
《河南医学研究》
CAS
2006年第3期247-249,共3页
Henan Medical Research
基金
湛江市科技攻关项目(编号:200521)
关键词
胆管癌
IL-6
P-选择素
ICAM-1
cholangiocarcinoma
IL-6
P-selectin
intercellular adhesion molecule-1
