摘要
目的了解创口感染病原菌的分布及对各类抗菌药物的耐药性,为临床合理用药提供依据。方法对2009年1月1日-2011年10月31日临床各种创口中分离的197株病原菌进行回顾性分析。结果 197株病原菌中,革兰阳性菌69株,占35.0%,革兰阴性菌102株,占51.8%;前3位的病原菌为铜绿假单胞菌、凝固酶阴性葡萄球菌、大肠埃希菌,分别占23.4%、17.3%、15.7%;MRSA和MRCNS检出率分别为25.0%、70.6%,未发现对糖肽类中介或耐药的金黄色葡萄球菌,未发现对万古霉素耐药的粪肠球菌和屎肠球菌;大肠埃希菌、肺炎克雷伯ESBLs检出率分别为66.7%、50.0%,未发现对亚胺培南耐药的肺炎克雷伯菌和肠杆菌属;检出多药耐药的铜绿假单胞菌1株,鲍氏不动杆菌2株。结论定期进行耐药监测有助于了解创口感染的病原菌耐药变迁,为临床用药提供依据。
OBJECTIVE To investigate the distribution and drug resistance of the pathogens causing wound infections so as to guide the reasonable clinical medication. METHODS A total of 197 strains of pathogens isolated from various clinical wounds between Jan 1 2009 and Oct 31, 2011 were retrospectively analyzed. RESULTS Among the 197 strailas of pathogens, there were 69（35.0%） strains of gram-positive bacteria and 102 （51.8%） strains of gram-negative bacteria. The Pseudomonas aeruginosa, coagulase-negative Staphylococci, and Esche- richia coli were the top three species of pathogens, accounting for 23. 4%, 17. 3%, 15. 7%, and 15. 7%, respectively; the detection rates of the MRSA and the MRCNS were 25.0% and 70.6% ; no strains of Staphylo- coccus aureus were found resistant or intermediate to glycosides antibiotics, and no strains of vancomycin-resistant Enterococcus faecalis or Enterococcus feces were detected, the detection rates of the ESBLs-producing E. coli and K, pneumoniae were 66.7 %and 50.0%, respectively; no strains of imipenem-resistant K. pneumoniae or Enter- obacter were found; there were 1 strain of multidrug-resistant P. aeruginosa and 2 strains of multidrug-resistant Acinetobacter baumannii isolated. CONCLUSION Regular monitoring of the drug resistance helps to understand the change in the drug resistance of pathogens causing wound infections , which provides basis for the clinical medication.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第15期3786-3787,3790,共3页
Chinese Journal of Nosocomiology
关键词
创口感染
病原菌
分布
耐药性
分析
Wound infection
Bacterial distribution
Druy resistance
Analysis
