摘要
目的探讨重症病毒性肝炎医院感染病原菌分布与危险因素。方法采取回顾性的方法调查分析2011年1月-2012年1月168例重症病毒性肝炎患者的临床资料,分析其病原菌分布和影响感染的危险因素。结果 168例重症病毒性肝炎患者78例发生医院感染,感染率为46.4%;医院感染的病原菌主要以大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌、金黄色葡萄球菌及白色假丝酵母菌为主,分别占26.7%、20.8%、14.2%、5.0%及33.3%;有肝硬化、免疫功能低下、抗菌药物不合理使用和侵入性操作以及高龄患者是影响感染的危险因素。结论重症病毒性肝炎医院感染患者的病原菌分布比较广泛,而且造成感染的因素也较多,在临床治疗中应规范操作,合理选用抗菌药物,可有效地降低感染的发生。
OBJECTIVE To study the risk factors for nosocomial infections caused by pathogenic bacteria in the patients with severe viral hepatitis. METHODS The clinical data of 168 cases of patients with severe viral hepatitis who were enrolled in the hospital from Jan 2011 to Jan 2012 were retrospectively analyzed, then the distribution of the pathogens and the risk factors were analyzed. RESULTS Of totally 168 severe viral hepatitis patients, the nosocomial infections occurred in 78 cases with the infection rate of 46.4%. The Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Candida albicans were the predominant species of pathogens causing the nosocomial infections, accounting for 26. 7%, 20. 8%, 14. 2%, 5.0%, and 33.3%, respectively. The liver cirrhosis foundation, low immune function, unreasonable use of antibiotics, invasive opera- tion, and advanced age were the risk factors for the nosocomial infections. CONCLUSION The species of pathogens causing nosocomial infections in the severe viral hepatitis patients distribute widely, and there are a number of factors leading to the infections, thus it is necessary to standardize the operation and reasonably use antibiotics during the clinical treatment so as to reduce the incidence of nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第15期3695-3696,3699,共3页
Chinese Journal of Nosocomiology
关键词
重症病毒性肝炎
医院感染
病原菌
危险因素
Severe viral hepatitis
Nosocomial infection
Pathogen
Risk factor
