摘要
目的:研究乙型肝炎病毒相关性肾炎(HBV-GN)的临床及病理情况。方法:回顾性分析82例HBV-GN患者的临床和病理资料。结果:82例HBV-GN患者中男48例,女34例,年龄6～70岁;临床诊断为肾病综合征51例、肾炎综合征20例、隐匿性肾炎7例、慢性肾衰竭4例。病理表现为膜性肾病(MN)50例(60.96%),膜增生性肾炎(MPGN)11例(13.41%),系膜增生性肾炎(MsPGN)7例(8.54%),IgA肾病(IgAN)6例(7.31%),增生硬化性肾小球肾炎(SGN)5例(6.10%),局灶性节段性肾小球硬化症(FSGS)2例(3.66%)。HBV-DNA与24 h尿蛋白定量(24hupr)及胱抑素c(CysC)的水平呈正相关。结论:HBV-GN其临床表现多样性,以肾病综合征最常见。病理类型以MN最多,其次为MPGN.
Objective To investigate the clinical and pathological features of hepatlts B virus associated glomerulonephritis （HBV - GN）. Method Clinical and pathological features were analyzed and correlated in 82 cases with renal biopsy - confirmed HBV - CN in our hospital from Jan 2000 to Oct 2012. Results 48 males and 34 females aged from 6 to 70 years old were included in this study. 82 patients were with HBV -GN diagnosed by renal biopsy. Syndrome was the most common clinical manifestation （51 cases）, followed by nephrotic syndrome （20 eases） and asymptomatic hematuria with or withom the presence of proteinuria（7cases） ,chronic renal failure（4cases）. In this study,renal biopsy data showed that membranous nephmpathy（MN） was the most frequent type with 50 cases （60. 96% ） ,followed by membranoproliferative glomerulanephritis （MPGN） with 11 cases（ 13.41 % ） and mesangial proliferative glomerulonephritis（MsPGN） 7 ca- ses（8.54% ） ,then IgA nephrepathy（IgAN） with 6 cases （7. 31% ） ,Sclerosing glomerulonephritis（SGN） with 5 cases（6.10% ） and focal segmental glomenalosclerosis （FSGS） 2 cases（3.66% ）. Analysis of correlation indicated that serum HBV -DNA correlated positively with 24 hours urine protein ration （24hupr） and cystatin c （CysC）. Conclusion The clinical manifestations of HBV - GN was diversity, themost in the common nephrotic syndrome. The pathological type was most of MN,followed by MPGN.
出处
《吉林医学》
CAS
2013年第25期5130-5132,共3页
Jilin Medical Journal
关键词
乙型肝炎病毒
肾炎
病理
肾活检
Hepatits B virus
Glomerulonephritis
Pathology
Renal biopsy
