摘要
目的研究多西他赛联合氟尿嘧啶和亚叶酸钙双周方案治疗晚期胃癌的临床疗效和不良反应。方法选择2009年6月—2011年8月我科收住的符合条件的晚期胃癌患者40例,治疗方案为多西他赛45mg/m2,静脉滴注1h;亚叶酸钙200mg/m2,静脉滴注2h;氟尿嘧啶375mg/m2,静脉推注10min;氟尿嘧啶2g/m2,静脉灌注46h,以上方案每2周重复1次,每2次为1个疗程,所有患者至少接受2个疗程的治疗。结果 40例均可评价疗效,有效率为62.5%(25/40);无治疗相关死亡,主要不良反应为骨髓抑制、口腔炎及脱发。结论多西他赛+氟尿嘧啶和亚叶酸钙联合化疗双周方案治疗晚期胃癌缓解率较高,不良反应耐受好,是治疗晚期胃癌安全有效的化疗方案。
Objective To research the effect adverse reactions of biweekly regimen of Docetaxel combined with Flu- orouracil and Leueovorin calcium in the treatment of advanced gastric cancer. Methods 40 cases were confirmed by pathological examination in patients with advanced gastric cancer, all the patients had measurable. Treatment options for Docetaxel 45mg/ m2, intravenous drip for 1 hours; Leueovorin calcium 200mg/m2, 2 hour infusion; Fluorouracil 375mg/m2, intravenous injec- tion of 10 minutes; Fluorouracil 2g/m2, intravenous infusion for 46 hours, the above scheme was repeated every 2 weeks, each 2 times for 1 course of treatment, all patients reeeived at least 2 courses. Results 40 patients could be evaluated, the effective rate was 62. 5% （25/40） ; There was no treatment related death, major adverse reactions were bone marrow suppression, sto- matitis and alopeeia. Conclusion The remission rate was high that Doeetaxel ＋ Fluorouracil and Leueovorin calcium combined chemotherapy biweekly regimen in the treatment of advanced gastric cancer, the adverse reaction is tolerant, which is a safe and effective chemotheranv scheme for advanced gastric cancer.
出处
《实用心脑肺血管病杂志》
2013年第9期81-82,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
多西他赛
醛氢叶酸
氟尿嘧啶
胃肿瘤
治疗结果
Docetaxel
Leucovorin
Fluorouracil
Gastric heoplasms
Treatment outcome
