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尤文肉瘤家族肿瘤染色体易位及靶向治疗的研究进展 被引量：4

Advances in chromosomal translocation and targeted therapy in Ewing sarcoma family of tumors
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摘要 许多骨与软组织肿瘤中存在染色体易位的现象,其中对尤文肉瘤家族肿瘤(Ewing sarcoma family of tumors,ESFT)中染色体易位的研究最早且最为深入。约85%左右的ESFT患者存在t(11;22)(q24;q12)染色体易位,由其编码的融合蛋白EWS/FLI1是导致ESFT发生和发展的关键因素。因此,对EWS/FLI1进一步研究可以为ESFT的诊断、治疗和预后等提供新的靶点。本文结合近几年的最新报道,对EWS/FLI1在ESFT发生和发展中的作用机制以及靶向治疗等方面的最新进展做一综述。 Chromosomal translocation exists in various of bone and soft tissue sarcomas,especially in ESFTs （Ewing sarcoma family of tumors）.Approximately 85% of ESFTs carry a t（11;22）（q24;q12） chromosomal translocation,which generates the fusion of the 5’ segment of EWS gene with the 3’ segment of FLI 1 gene.The resultant EWS/FLI1 fusion protein promotes oncongenesis by altering the expression of its target genes,and it is necessary for the progression of ESFTs.Therefore,EWS/FLI1 has been a new target for studies on the diagnosis,treatment modality and prognosis of ESFTs.This review summarizes recent progress in research on EWS/FLI1 mechanism during the initiation and progression of ESFTs and its targeted therapy.
作者 汪红胜 孙梦熊 华莹奇 蔡郑东
机构地区 同济大学附属第十人民医院骨科
出处 《肿瘤》 CAS CSCD 北大核心 2013年第8期748-752,共5页 Tumor
关键词 肉瘤 Ewing 易位 遗传 基因疗法 癌基因蛋白质类 融合 EWS FLI1 ESFT Sarcoma Ewing’s Translocation genetic Gene therapy Oncogene proteins fusion EWS/ FLI1 ESFT
分类号 R738.6 [医药卫生—肿瘤]
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参考文献43

  • 1LISSAT A, CHAO M M, KONTNY U. Targeted therapy in Ewing sarcoma[J]. ISRN Oncol, 2012,2012:609439.
  • 2LUDWIG J A. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future[J]. Curt Opin Oncol, 2008, 20(4):412-418.
  • 3RIGGI N, STAMENKOVlC I. The BioJogy of Ewing sarcoma[J]. Cancer lett, 2007, 254(1 ):1 - 10.
  • 4SANKAR S, LESSNICK S L. Promiscuous partnerships in Ewing's sarcoma[J]. Cancer Genet, 2011, 204(7):351-365.
  • 5NG T L, O'SULLIVAN M J, PALLEN C J, et al. Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV[J]. J Mol Diagn, 2007, 9(4):459-463.
  • 6TAN A Y, MANLEY J L. The TET family of proteins: functions and ro(es in disease[J]. J Mol Cell &iol, 2009, 1 (2):82-92.
  • 7SETH A, WATSON D K. ETS transcription factors and their emerging roles in human cancer[j]. EurJ Cancer, 2005, 41 (16):2462-2478.
  • 8SZUHAI K, USZENGA M, DE JONG D, et al. The NFATc2gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology[j]. C/in Cancer Res, 2009, 15(7):2259-2268.
  • 9CHEW J L, LOH Y H, ZHANG W, et al. Reciprocal transcriptional regulation of Pou5fl and Sox2 via the Oct4/Sox2 complex in embryonic stem cells[J]. Mol Cell Biol, 2005, 25(14):6031-6046.
  • 10SUMEGI J, NISHIO J, NELSON M, et al. A novel t(4;22)(q31 ;ql 2) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor[J]. Mod Pathol, 2011,24(3):333-342.

二级参考文献6

  • 1ANGELJ R, ALFRED A, SAKHUJA A, etal. Ewing's sarcoma of the kidney[J]. IntJ Clin Oncol, 201 O, 15(3):314-318.
  • 2POMARA G, CAPPELLA F, CUTTANO M G, et al. Primitive neuroectodermal tumor (PNET) of the kidney: a case report[J]. BMC Cancer, 2004, 4:3.
  • 3MARLEY E F, LIAPIS H, HUMPHREY P A, et al. Primitive neuroectodermal tumor of the kidney-another enigma:a pathologic, immunohistochemical,and molecular diagnostic study[J]. AmJ Surg Pathol, 1997, 21(3):354-359.
  • 4PARHAM D M, ROLOSON G J, FEELY M, et al. Primary malignant neuroepithelial tumors of the kidney:a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms' Tumor Study Group Pathology Center]. Am J Surg Pathol, 2001, 25(2):133-146.
  • 5JUAN C J, WU C J,CHEN C Y, et al. Primitive neuroectodermal tumor of the Kidney associated with Budd-Chiari syndrome in a 17-year-old girl[J].J Formos MedAssoc, 2001, 100(9):628-630.
  • 6THYAVIHALLY Y B, TONGAONKAR H B, GUPTA S, et al. Primitive neuroectodermal tumor of the kidney: a single institute series of 16 patients[J]. Urology, 2008, 71(2):292-296.

共引文献4

同被引文献37

  • 1赵尔增,张建中,景青萍,张铭.外周性原始神经外胚层瘤的临床病理及免疫组织化学特征[J].中华肿瘤防治杂志,2006,13(13):994-997. 被引量：13
  • 2Basharkhah A,Pansy J, Urban C, et al. Outcomes after interdis- ciplinary management of 7 patients with Askin tumor[J]. Pedi- atr Surg Int,2013,29(5) :431-436.
  • 3Askin FB,Rosai J, Sibley RK, eta[. Malignant small ceil tumor of the thoracopulmonary region in childhood:a distinctive clinico- pathologic entity of uncertain histogenesisFJ. Cancer, 1979, 43 (6) : 2438-2451.
  • 4Murphey MD,Senchak LT,Mambalam PK,et al. From the radiolog- ic pathology archives: ewing sarcoma family of tumors: radiologic- pathologic correlation[J]. Radiographics,2013,33(3):803-831.
  • 5Lee AF, Hayes MM, Lebrun D, et al. FLi-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondro- sarcoma [J]. Appl Immunohistochem Mol Morphol, 2011, 19(3) : 233-238.
  • 6Dou X,Yan H,Wang R. Treatment of an Askin tumor A case report and review of the literature[J]. Oncol Lett, 2013,6 (4) 985-989.
  • 7Sirivella S,Gielchinsky I. Treatment outcomes in 23 thoracic primi- tive neuroectodermaI tumours:a retrospective study[J]. Interact Car- diovasc Thorac Surg,2013,17(2) :273-279.
  • 8彭柔君,孙晓非,向晓娟,甄子俊,凌家瑜,童纲领,夏奕,徐光川,姜文奇.92例初治尤文氏肉瘤家族肿瘤综合治疗疗效和生存分析[J].癌症,2009,28(12):1304-1309. 被引量：8
  • 9赵金华,黄路,陈文昭,曹凯,安洪,袁铿,舒勇,黄山虎,廖翔,张战民,邓高荣.尤文肉瘤EWS-FLI1蛋白HLA-A2.1限制性CTL表位的预测、筛选及鉴定[J].免疫学杂志,2010,26(1):10-15. 被引量：4
  • 10洪国斌,邬伟明,陈凯,冯晓新,梁碧玲.脊柱原始神经外胚层肿瘤的临床特点和影像学分析[J].中华肿瘤防治杂志,2010,17(13):1025-1027. 被引量：9

引证文献4

二级引证文献20

肿瘤
2013年 第8期

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