摘要
目的比较三阴性乳腺癌和非三阴性乳腺癌临床特征及预后。方法对我院2003年-2010年期间住院治疗的560例乳腺癌患者临床资料进行回顾性分析。比较三阴乳腺癌及非三阴乳腺癌的3年、5年生存率及临床特征的差别。结果三阴乳腺癌患者的3年生存率及5年生存率为85.5%和73.3%,显著低于非三阴乳腺癌患者(95.1%和88.0%,P<0.05);三阴乳腺癌患者复发率和远行转移率显著高于对照组(P<0.05);三阴乳腺癌患者发病年龄较轻,肿瘤体积较大,与非三阴乳腺癌患者相比差异有统计学意义(P<0.05);Cox多因素分析结果显示:是否为三阴性、肿瘤大小是影响患者预后的独立影响因素。结论三阴性乳腺癌有独特的临床病理特征,易发生复发及转移,预后差。
Objective To compare the clinical characteristics and prognosis between triple-negative（TNBC） and non-triple-negative breast cancer（NTNBC）.Methods From 2003 to 2010,560 hospitalized invasive breast cancer patients were retrospectively analyzed.3 year,5 year survival rate and clinical characteristics were compared between TNBC and NTNBC.Results In patients with TNBC,3-and 5-year survival rate were 85.5% and 73.3%,respectively.Which were significantly lower than that in NTNBC patients（95.1% and 88.0%,P〈0.05）.Recurrence and metastasis rate of TNBC patients were significantly higher than that in control group（P〈0.05）.Compared with NTNBC patients,TNBC patients were with a younger age at onset and larger tumor size（P〈0.05）.Cox multivariate analysis showed that TNBC and tumor size were independent prognostic factors.Conclusion TNBC has unique clinical characteristics.It tends to recurrence and metastasis,leading to a poor prognosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第8期786-788,共3页
Cancer Research on Prevention and Treatment
关键词
三阴性乳腺癌
非三阴性乳腺癌
临床特征
Triple-negative breast cancer
Non-triple-negative breast cancer
Clinical characteristics
