摘要
目的探讨前列地尔治疗肺动脉高压合并咯血的临床疗效。方法将40例肺动脉高压合并咯血患者按随机数字表法分为治疗组与对照组,每组20例。2组均给予基础病常规治疗,在此基础上治疗组加用前列地尔,剂量20μg+20 mL生理盐水,微量泵泵入,每日1次(速度1μg.min-1);对照组应用酚妥拉明20 mg溶于5%葡萄糖注射液250 mL静脉滴注,每日1次。比较2组咯血缓解情况及治疗前后肺动脉压力的变化。结果治疗组咯血缓解情况明显优于对照组,2组总有效率相比差异有统计学意义(90%比50%,P<0.05);2组治疗后肺动脉压较治疗前均显著降低(P<0.05),但治疗组治疗后与对照组相比肺动脉压降低更为显著(P<0.05)。结论前列地尔在显著降低肺动脉高压的基础上,对咯血有着较好的疗效。
Objective To investigate the clinical pulmonary hypertension. Methods Forty patients with effect of alprostadil on hemoptysis caused by pulmonary hypertension and hemoptysis were randomly divided into two groups, with 20 patients in each group. All patients received conventional therapy. In addition, the treatment group was given alprostadil （20 μg in 20 mL normal saline）once per day via micro-pump （1 μg·min-1）. The control group was given intravenous infusion of phentolamine （20 mg in 250 mL 5% glucose injection）once per day. The remission of hemoptysis and the changes in pulmonary arterial pressure before and after treatment were compared between the two groups. Results Compared with control group, the remission rate of hemoptysis significantly increased in treatment group （90% vs 50%, P〈0.05）. Pulmonary artery pressure significantly reduced after treatment in both groups （P〈0.05）. However, the reduction in treatment group was more obvious than that in control group （P〈 0.05）. Conclusion Alprostadil can remarkably decrease pulmonary hypertension and effectively treat hemoptysis.
出处
《实用临床医学（江西）》
CAS
2013年第6期38-39,42,共3页
Practical Clinical Medicine
关键词
肺动脉高压
咯血
前列地尔
酚妥拉明
pulmonary hypertension
hemoptysis
alprostadil
phentolamine
